ID   DML1_YEAST              Reviewed;         475 AA.
AC   Q03652; D6W036;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Protein DML1;
DE   AltName: Full=Drosophila melanogaster misato-like protein 1;
GN   Name=DML1; OrderedLocusNames=YMR211W; ORFNames=YM8261.05;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=12702300; DOI=10.1016/s1567-1356(02)00083-1;
RA   Gurvitz A., Hartig A., Ruis H., Hamilton B., de Couet H.G.;
RT   "Preliminary characterisation of DML1, an essential Saccharomyces
RT   cerevisiae gene related to misato of Drosophila melanogaster.";
RL   FEMS Yeast Res. 2:123-135(2002).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14690591; DOI=10.1016/s1097-2765(03)00476-3;
RA   Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M.,
RA   Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E.,
RA   Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.;
RT   "Assigning function to yeast proteins by integration of technologies.";
RL   Mol. Cell 12:1353-1365(2003).
CC   -!- FUNCTION: Involved in the partitioning of the mitochondrial organelle
CC       and mitochondrial DNA (mtDNA) inheritance.
CC       {ECO:0000269|PubMed:12702300}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12702300}.
CC       Mitochondrion {ECO:0000269|PubMed:12702300,
CC       ECO:0000269|PubMed:14690591}.
CC   -!- SIMILARITY: Belongs to the misato family. {ECO:0000305}.
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DR   EMBL; Z49809; CAA89926.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10110.1; -; Genomic_DNA.
DR   PIR; S55093; S55093.
DR   RefSeq; NP_013938.1; NM_001182718.1.
DR   AlphaFoldDB; Q03652; -.
DR   BioGRID; 35389; 63.
DR   DIP; DIP-1270N; -.
DR   IntAct; Q03652; 2.
DR   MINT; Q03652; -.
DR   STRING; 4932.YMR211W; -.
DR   MaxQB; Q03652; -.
DR   PaxDb; Q03652; -.
DR   PRIDE; Q03652; -.
DR   EnsemblFungi; YMR211W_mRNA; YMR211W; YMR211W.
DR   GeneID; 855251; -.
DR   KEGG; sce:YMR211W; -.
DR   SGD; S000004824; DML1.
DR   VEuPathDB; FungiDB:YMR211W; -.
DR   eggNOG; KOG2530; Eukaryota.
DR   GeneTree; ENSGT00530000064067; -.
DR   HOGENOM; CLU_022511_2_2_1; -.
DR   InParanoid; Q03652; -.
DR   OMA; DNGWGGF; -.
DR   BioCyc; YEAST:G3O-32894-MON; -.
DR   PRO; PR:Q03652; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03652; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IMP:SGD.
DR   GO; GO:0048311; P:mitochondrion distribution; IBA:GO_Central.
DR   GO; GO:0006276; P:plasmid maintenance; IMP:SGD.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR029209; DML1/Misato_tubulin.
DR   InterPro; IPR019605; Misato_II_tubulin-like.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   Pfam; PF10644; Misat_Tub_SegII; 1.
DR   Pfam; PF14881; Tubulin_3; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Protein DML1"
FT                   /id="PRO_0000203331"
SQ   SEQUENCE   475 AA;  55312 MW;  A24CA4E6BA9DC146 CRC64;
     MHEVVTISVS QRANHLTTQF FNIQEGYLQL SKEQQVNDSK IFLNSVVDKV SKTISYAPRA
     LLWDARTGNG SLGTYQYSES QDYHFGNEDK FKEQTVIKTH PRIPKSEYQS SLDAGAPLPC
     LNRENTMYWS DYSKLIYGPS SFNILRNWYH DTENPNQPDF QNLGERKFDR YSIGYDEFTE
     NYLQEFFDGN LHRELEKCDT LQGFNLVSDM ESGWGGFSSA LLVELRNELP KKAVFSWGHN
     EDDPFTDDFP MKRLSKKWLP IISNKLRSTI NMMQESDLYF PLYAAPGLTN WETAGKSCRI
     FDSINATISQ SNLEQRKTMD YLTTAITLGY SSRNMVTGMV IGDTDYSFCS RVLPFKNSHK
     PNSTHIFSKS FIDRGNQTHK HHSEPDSRSK MIEMYTHRYF PSDTIPTEFS NDREFVLELE
     SSEKNRDIFK HWNEFVVRYF KNDSDREELK NELSDYASAY ESGWYEDEDS GDDDM