DMP1_ARATH
ID DMP1_ARATH Reviewed; 207 AA.
AC Q9LVF4;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein DMP1 {ECO:0000303|PubMed:20712629};
DE Short=AtDMP1 {ECO:0000303|PubMed:20712629};
GN Name=DMP1 {ECO:0000303|PubMed:20712629};
GN OrderedLocusNames=At3g21520 {ECO:0000312|Araport:AT3G21520};
GN ORFNames=MIL23.9 {ECO:0000312|EMBL:BAB02347.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GENE FAMILY,
RP AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=20712629; DOI=10.1111/j.1438-8677.2010.00381.x;
RA Kasaras A., Kunze R.;
RT "Expression, localisation and phylogeny of a novel family of plant-specific
RT membrane proteins.";
RL Plant Biol. 12 Suppl. 1:140-152(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=22530652; DOI=10.1186/1471-2229-12-54;
RA Kasaras A., Melzer M., Kunze R.;
RT "Arabidopsis senescence-associated protein DMP1 is involved in membrane
RT remodeling of the ER and tonoplast.";
RL BMC Plant Biol. 12:54-54(2012).
CC -!- FUNCTION: Involved in membrane remodeling including fission during
CC breakdown of the endoplasmic reticulum (ER) and the tonoplast during
CC leaf senescence and in membrane fusion during vacuole biogenesis in
CC roots. {ECO:0000269|PubMed:22530652}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:20712629, ECO:0000269|PubMed:22530652}; Multi-pass
CC membrane protein {ECO:0000255}. Vacuole membrane
CC {ECO:0000269|PubMed:20712629, ECO:0000269|PubMed:22530652}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, siliques and roots.
CC {ECO:0000269|PubMed:20712629, ECO:0000269|PubMed:22530652}.
CC -!- DEVELOPMENTAL STAGE: Accumulates in tissues undergoing senescence
CC (PubMed:20712629, PubMed:22530652). In roots tips, strongly expressed
CC in the cortex undergoing vacuole biogenesis (PubMed:22530652).
CC {ECO:0000269|PubMed:20712629, ECO:0000269|PubMed:22530652}.
CC -!- SIMILARITY: Belongs to the plant DMP1 protein family. {ECO:0000305}.
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DR EMBL; AB019232; BAB02347.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76519.1; -; Genomic_DNA.
DR EMBL; AY080599; AAL85010.1; -; mRNA.
DR EMBL; AY114034; AAM45082.1; -; mRNA.
DR RefSeq; NP_188789.2; NM_113047.3.
DR AlphaFoldDB; Q9LVF4; -.
DR STRING; 3702.AT3G21520.1; -.
DR PaxDb; Q9LVF4; -.
DR PRIDE; Q9LVF4; -.
DR ProteomicsDB; 224125; -.
DR EnsemblPlants; AT3G21520.1; AT3G21520.1; AT3G21520.
DR GeneID; 821706; -.
DR Gramene; AT3G21520.1; AT3G21520.1; AT3G21520.
DR KEGG; ath:AT3G21520; -.
DR Araport; AT3G21520; -.
DR TAIR; locus:2089915; AT3G21520.
DR eggNOG; ENOG502R6TY; Eukaryota.
DR HOGENOM; CLU_075936_2_0_1; -.
DR InParanoid; Q9LVF4; -.
DR OMA; FTNEGHC; -.
DR OrthoDB; 1324884at2759; -.
DR PhylomeDB; Q9LVF4; -.
DR PRO; PR:Q9LVF4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVF4; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
DR GO; GO:0010256; P:endomembrane system organization; IMP:TAIR.
DR GO; GO:0090158; P:endoplasmic reticulum membrane organization; IDA:UniProtKB.
DR GO; GO:0090148; P:membrane fission; IDA:UniProtKB.
DR GO; GO:0061025; P:membrane fusion; IDA:UniProtKB.
DR GO; GO:0090693; P:plant organ senescence; IEP:UniProtKB.
DR InterPro; IPR007770; DMP.
DR PANTHER; PTHR31621; PTHR31621; 1.
DR Pfam; PF05078; DUF679; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Vacuole.
FT CHAIN 1..207
FT /note="Protein DMP1"
FT /id="PRO_0000441608"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22058 MW; D28A02947BC995FE CRC64;
MSETSLLIPK TNSPASSENM ANTNKSLTGL ESLIKLLPTG TLFIYLLLNP VLTNDGECST
GNKVMSSILV ALCSFSCVFS CFTDSFKGVD GSRKFGIVTK KGLWTYAEPG SVDLSKYKLR
IADFVHAGFV LAVFGTLVLL DANTASCFYP RFRETQKTLV MALPPAVGVA SATIFALFPS
KRSGIGYAPI AEEVGAEEET KKASVSA
