DMR14_CRYX8
ID DMR14_CRYX8 Reviewed; 436 AA.
AC A0A4P8DK24;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 31-JUL-2019, sequence version 1.
DT 03-AUG-2022, entry version 11.
DE RecName: Full=Transcriptional regulator dmxR14 {ECO:0000303|PubMed:30996871};
DE AltName: Full=Dimeric xanthone biosynthesis cluster protein R14 {ECO:0000303|PubMed:30996871};
GN Name=dmxR14 {ECO:0000303|PubMed:30996871};
OS Cryptosporiopsis sp. (strain 8999).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Dermateaceae; Cryptosporiopsis; unclassified Cryptosporiopsis.
OX NCBI_TaxID=2572248;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=8999;
RX PubMed=30996871; DOI=10.1039/c8sc05126g;
RA Greco C., de Mattos-Shipley K., Bailey A.M., Mulholland N.P., Vincent J.L.,
RA Willis C.L., Cox R.J., Simpson T.J.;
RT "Structure revision of cryptosporioptides and determination of the genetic
RT basis for dimeric xanthone biosynthesis in fungi.";
RL Chem. Sci. 10:2930-2939(2019).
CC -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC mediates the biosynthesis of the dimeric xanthones cryptosporioptides.
CC {ECO:0000269|PubMed:30996871}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; MK182094; QCL09105.1; -; Genomic_DNA.
DR SMR; A0A4P8DK24; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR013700; AflR.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF08493; AflR; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..436
FT /note="Transcriptional regulator dmxR14"
FT /id="PRO_0000453507"
FT DNA_BIND 34..61
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 47332 MW; B94001D3437BEDB6 CRC64;
MEEAETNTQV DSVPSNSVRS GAELSSKSKL RDSCHACARS KVRCPKQKPS CSRCEARGTT
CQYFFSRRPG RRRETSKSPN PEKQIAIGSS HANNRNSPSF SSTRSTLPSP IASDSNSNFT
QPQNSSITTV HNGPENSIES PCWEDFSCEF SDTDFVMPTI DTPFDLSPAY SGSVVQEMND
TAPFPLSSSR ISMGTTPSGK SSISSYSQIL PSITPTTTPV AHISSCRCLA TALDLLKTLS
LAGLADADSL VSAPIILAEN KQSIESVNNL MACPLCSGDS FPLTIFSMIA LKILERYAVA
ARTQHQGTRP QEAEGTVEIK LADIVISNNE DQTRLPSHSN IVCCDDKTQA RAAAQLVLGE
LHHMQRLVNQ LSSMIKRSAE RDGRKLEILN GYNDSIDSGN SMLASFSAST LELVESDVRK
SLRSLSTDII KELRQH