DMRT1_BOVIN
ID DMRT1_BOVIN Reviewed; 357 AA.
AC C0LZJ1; F1MYB6; Q32LL0;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Doublesex and mab-3 related transcription factor 1;
GN Name=DMRT1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=20016168; DOI=10.1159/000245918;
RA Bratus A., Slota E.;
RT "Comparative cytogenetic and molecular studies of DM domain genes in pig
RT and cattle.";
RL Cytogenet. Genome Res. 126:180-185(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a key role in male sex
CC determination and differentiation by controlling testis development and
CC male germ cell proliferation. Plays a central role in spermatogonia by
CC inhibiting meiosis in undifferentiated spermatogonia and promoting
CC mitosis, leading to spermatogonial development and allowing abundant
CC and continuous production of sperm. Acts both as a transcription
CC repressor and activator: prevents meiosis by restricting retinoic acid
CC (RA)-dependent transcription and repressing STRA8 expression and
CC promotes spermatogonial development by activating spermatogonial
CC differentiation genes, such as SOHLH1. Also plays a key role in
CC postnatal sex maintenance by maintaining testis determination and
CC preventing feminization: represses transcription of female promoting
CC genes such as FOXL2 and activates male-specific genes. May act as a
CC tumor suppressor. May also play a minor role in oogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI09528.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; FJ790227; ACN86339.1; -; mRNA.
DR EMBL; DAAA02022773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02022774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02022775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02022776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03096871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109527; AAI09528.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001071528.1; NM_001078060.1.
DR AlphaFoldDB; C0LZJ1; -.
DR SMR; C0LZJ1; -.
DR STRING; 9913.ENSBTAP00000023667; -.
DR PaxDb; C0LZJ1; -.
DR GeneID; 616245; -.
DR KEGG; bta:616245; -.
DR CTD; 1761; -.
DR eggNOG; KOG3815; Eukaryota.
DR InParanoid; C0LZJ1; -.
DR OrthoDB; 1209937at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0002176; P:male germ cell proliferation; ISS:UniProtKB.
DR GO; GO:0030238; P:male sex determination; ISS:UniProtKB.
DR GO; GO:0046661; P:male sex differentiation; ISS:UniProtKB.
DR GO; GO:0045835; P:negative regulation of meiotic nuclear division; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 3.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW Sexual differentiation; Transcription; Transcription regulation;
KW Tumor suppressor; Zinc.
FT CHAIN 1..357
FT /note="Doublesex and mab-3 related transcription factor 1"
FT /id="PRO_0000416898"
FT DNA_BIND 58..105
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZ59"
FT CONFLICT 307
FT /note="A -> V (in Ref. 1; ACN86339 and 4; AAI09528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 37909 MW; EA43A6F3F02F9163 CRC64;
MPNDDAYSKP SAPSEAPQTP GAPPQGKAGG GGGGSGSDSG ASGTGAVSGK KSPRLPKCAR
CRNHGYASPL KGHKRFCMWR DCQCKKCNLI AERQRVMAAQ VALRRQQAQE EELGISHPIP
LPSTAELMVK RENSSGNPCL MIESSSSSQP PPASTPSTAA PGPEGRMVIQ DIPAVTSRGH
VENTPDLVSD STYYSSFYQP SLFPYYNNLY NYPQYPMALA ADSSSGDVGN PLGGSPVKNS
LRSLPAPYVP GQTGNQWQMK NSENRHAVSS QYRMHSYYPP PSYLGQSMSQ IFTFEDSASY
SEAKASAFSP PSSQDSGLVS LPSSSPIGNE STKAVLDCES ASEPSNFAVA PIIEEDE
