DMRT1_DANRE
ID DMRT1_DANRE Reviewed; 267 AA.
AC Q71MM5; A2BFC0; C9K0Z3; Q6YDI0; Q6YDI3; Q6YDI6;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 1;
GN Name=dmrt1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RX PubMed=15809088; DOI=10.1016/j.bbrc.2005.03.066;
RA Guo Y., Cheng H., Huang X., Gao S., Yu H., Zhou R.;
RT "Gene structure, multiple alternative splicing, and expression in gonads of
RT zebrafish Dmrt1.";
RL Biochem. Biophys. Res. Commun. 330:950-957(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17937319; DOI=10.1021/es070785+;
RA Schulz R.W., Bogerd J., Male R., Ball J., Fenske M., Olsen L.C.,
RA Tyler C.R.;
RT "Estrogen-induced alterations in amh and dmrt1 expression signal for
RT disruption in male sexual development in the zebrafish.";
RL Environ. Sci. Technol. 41:6305-6310(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RA Zhang J., Song P.;
RT "Molecular cloning and expression pattern of two alternatively spliced
RT transcripts of dmrt1 gene in zebrafish.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-267.
RC TISSUE=Testis;
RA Kobayashi T., Kajiura-Kobayashi H., Nagahama Y.;
RT "DMRT1 expression during gonadal differentiation and development in
RT teleosts.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a key role in sex
CC determination and differentiation by controlling gonad development and
CC germ cell proliferation. Acts both as a transcription repressor and
CC activator (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=a;
CC IsoId=Q71MM5-1; Sequence=Displayed;
CC Name=2; Synonyms=b;
CC IsoId=Q71MM5-2; Sequence=VSP_042997;
CC Name=3; Synonyms=c;
CC IsoId=Q71MM5-3; Sequence=VSP_042995, VSP_042996;
CC -!- TISSUE SPECIFICITY: Expressed in developing germ cells of both testis
CC and ovary. {ECO:0000269|PubMed:15809088}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM14465.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM16633.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY157561; AAN61060.1; -; mRNA.
DR EMBL; AY157562; AAN61061.1; -; mRNA.
DR EMBL; AY157565; AAN61064.1; -; mRNA.
DR EMBL; AY157567; AAN61066.1; -; mRNA.
DR EMBL; AY157568; AAN61067.1; -; mRNA.
DR EMBL; AY157569; AAN61068.1; -; mRNA.
DR EMBL; AY157570; AAN61069.1; -; mRNA.
DR EMBL; AY157571; AAN61070.1; -; mRNA.
DR EMBL; AF439562; AAQ04555.1; -; mRNA.
DR EMBL; AY588966; AAU04562.1; -; mRNA.
DR EMBL; CR388096; CAM14465.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BX255951; CAM14465.1; JOINED; Genomic_DNA.
DR EMBL; BX255951; CAM16633.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR388096; CAM16633.1; JOINED; Genomic_DNA.
DR EMBL; BC116610; AAI16611.1; -; mRNA.
DR EMBL; AB127117; BAI44628.1; -; mRNA.
DR RefSeq; NP_991191.2; NM_205628.2. [Q71MM5-1]
DR RefSeq; NP_991324.2; NM_205761.2. [Q71MM5-3]
DR AlphaFoldDB; Q71MM5; -.
DR SMR; Q71MM5; -.
DR STRING; 7955.ENSDARP00000108943; -.
DR PaxDb; Q71MM5; -.
DR Ensembl; ENSDART00000130428; ENSDARP00000107644; ENSDARG00000007349. [Q71MM5-1]
DR GeneID; 402923; -.
DR KEGG; dre:402923; -.
DR CTD; 1761; -.
DR ZFIN; ZDB-GENE-050511-1; dmrt1.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000156489; -.
DR InParanoid; Q71MM5; -.
DR OMA; CLMTECS; -.
DR OrthoDB; 1209937at2759; -.
DR PhylomeDB; Q71MM5; -.
DR TreeFam; TF317837; -.
DR PRO; PR:Q71MM5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000007349; Expressed in testis and 17 other tissues.
DR ExpressionAtlas; Q71MM5; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IMP:ZFIN.
DR GO; GO:0002176; P:male germ cell proliferation; IMP:ZFIN.
DR GO; GO:0008584; P:male gonad development; IMP:ZFIN.
DR GO; GO:0030238; P:male sex determination; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; Differentiation;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..267
FT /note="Doublesex- and mab-3-related transcription factor 1"
FT /id="PRO_0000416899"
FT DNA_BIND 22..69
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 102..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 125..132
FT /note="SRSMLSLS -> EENTLVMI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15809088"
FT /id="VSP_042995"
FT VAR_SEQ 133..267
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15809088"
FT /id="VSP_042996"
FT VAR_SEQ 224..267
FT /note="AFSDGAQDSVSISSMINAENKLECESSSESGSFSVDSIIEGATK -> GRSH
FT THTHTHTHTHTLLGP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15809088"
FT /id="VSP_042997"
FT CONFLICT 9
FT /note="G -> R (in Ref. 1; AAN61061/AAN61060/AAN61064/
FT AAN61070/AAN61069/AAN61068/AAN61067/AAN61066)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="N -> D (in Ref. 1; AAN61061/AAN61060)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="E -> G (in Ref. 1; AAN61061/AAN61060)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 29092 MW; F9CC415613FD8EEA CRC64;
MSEEEQTNGS LSIRKPSRMP KCSRCRNHGF VSPLKGHKRF CNWRDCQCQK CRLIAERQRV
MAAQVALRRQ QAQEEEMGIC SPINLSGSDT LVKNEAVGEN VFTLSSGPPS PASSSATASP
TNLGSRSMLS LSPAMSSRGH TDCTSDLMVD ASYYNLYQPT PYSSYYSNLY NYQQYQMPSG
NGRLSSHNVS PQYRTHSYYS SYLSQGLGAA CVQPSTCPEP KAAAFSDGAQ DSVSISSMIN
AENKLECESS SESGSFSVDS IIEGATK
