DMRT1_ORYLA
ID DMRT1_ORYLA Reviewed; 280 AA.
AC Q801F8; Q90XZ5; Q90XZ8;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 1;
GN Name=dmrt1; Synonyms=dmrt1a;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Carolina Biological;
RX PubMed=11543627; DOI=10.1006/geno.2001.6615;
RA Brunner B., Hornung U., Shan Z., Nanda I., Kondo M., Zend-Ajusch E.,
RA Haaf T., Ropers H.-H., Shima A., Schmid M., Kalscheuer V.M., Schartl M.;
RT "Genomic organization and expression of the doublesex-related gene cluster
RT in vertebrates and detection of putative regulatory regions for DMRT1.";
RL Genomics 77:8-17(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HNI;
RX PubMed=12620191; DOI=10.1016/s0960-9822(03)00125-8;
RA Kondo M., Nanda I., Hornung U., Asakawa S., Shimizu N., Mitani H.,
RA Schmid M., Shima A., Schartl M.;
RT "Absence of the candidate male sex-determining gene dmrt1b(Y) of medaka
RT from other fish species.";
RL Curr. Biol. 13:416-420(2003).
RN [3]
RP DEVELOPMENTAL STAGE.
RC STRAIN=HNI;
RX PubMed=12037570; DOI=10.1038/nature751;
RA Matsuda M., Nagahama Y., Shinomiya A., Sato T., Matsuda C., Kobayashi T.,
RA Morrey C.E., Shibata N., Asakawa S., Shimizu N., Hori H., Hamaguchi S.,
RA Sakaizumi M.;
RT "DMY is a Y-specific DM-domain gene required for male development in the
RT medaka fish.";
RL Nature 417:559-563(2002).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=HNI;
RX PubMed=12193652; DOI=10.1073/pnas.182314699;
RA Nanda I., Kondo M., Hornung U., Asakawa S., Winkler C., Shimizu A.,
RA Shan Z., Haaf T., Shimizu N., Shima A., Schmid M., Schartl M.;
RT "A duplicated copy of DMRT1 in the sex-determining region of the Y
RT chromosome of the medaka, Oryzias latipes.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11778-11783(2002).
CC -!- FUNCTION: Transcription factor that acts both as a transcription.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Testis-specific. Localizes to Sertoli cells.
CC {ECO:0000269|PubMed:12193652}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in embryos. Expression starts around
CC day 20. {ECO:0000269|PubMed:12037570, ECO:0000269|PubMed:12193652}.
CC -!- MISCELLANEOUS: In contrast to dmrt1y/dmy paralog, which plays a key
CC role in male sex determination, its role is unclear (PubMed:12037570
CC and PubMed:12193652).
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AF319991; AAL02162.1; -; Genomic_DNA.
DR EMBL; AF319994; AAL02165.1; -; mRNA.
DR EMBL; AY157712; AAO23674.1; -; Genomic_DNA.
DR AlphaFoldDB; Q801F8; -.
DR SMR; Q801F8; -.
DR STRING; 8090.ENSORLP00000025778; -.
DR PRIDE; Q801F8; -.
DR Ensembl; ENSORLT00020020312; ENSORLP00020029782; ENSORLG00020013974.
DR eggNOG; KOG3815; Eukaryota.
DR InParanoid; Q801F8; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..280
FT /note="Doublesex- and mab-3-related transcription factor 1"
FT /id="PRO_0000416900"
FT DNA_BIND 27..74
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="G -> A (in Ref. 1; AAL02162)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="R -> G (in Ref. 1; AAL02165)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="M -> T (in Ref. 1; AAL02162/AAL02165)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="A -> T (in Ref. 1; AAL02165)"
FT /evidence="ECO:0000305"
FT CONFLICT 117
FT /note="A -> G (in Ref. 1; AAL02162/AAL02165)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="Missing (in Ref. 1; AAL02165)"
FT /evidence="ECO:0000305"
FT CONFLICT 279
FT /note="T -> S (in Ref. 1; AAL02165)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 30294 MW; D041CAA6D32C161B CRC64;
MSKEKQGRPV PEGPAPGPQR SPRMPKCSRC RNHGFVSPLK GHKRFCRWKD CRCAKCKLIA
ERQRVMAAQV ALRRQQAQEE ELGICSPEAS SGPEVMVKNE AGADCLFSME GRSGTPAVPP
NPLSAAGSCS ASSSSPSAAA RVYGEEASDL LLETSYYNFY QPSRYSSYYG NLYQQYQQMP
PSDGRLSGHS MPSQYRMHSF YPGTAYLPQG LGSPVPPYFS LEDNDGAAAS FSPSSLTSTH
DSTLTCRSIS SLVNVGVKAE FESGGQPSVF PADSMSSETK
