DMRT1_PIG
ID DMRT1_PIG Reviewed; 373 AA.
AC Q9TT01;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 1;
GN Name=DMRT1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Dornan S.C., Daneau I., Lussier J.G., Silversides D.W.;
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a key role in male sex
CC determination and differentiation by controlling testis development and
CC male germ cell proliferation. Plays a central role in spermatogonia by
CC inhibiting meiosis in undifferentiated spermatogonia and promoting
CC mitosis, leading to spermatogonial development and allowing abundant
CC and continuous production of sperm. Acts both as a transcription
CC repressor and activator: prevents meiosis by restricting retinoic acid
CC (RA)-dependent transcription and repressing STRA8 expression and
CC promotes spermatogonial development by activating spermatogonial
CC differentiation genes, such as SOHLH1. Also plays a key role in
CC postnatal sex maintenance by maintaining testis determination and
CC preventing feminization: represses transcription of female promoting
CC genes such as FOXL2 and activates male-specific genes. May act as a
CC tumor suppressor. May also play a minor role in oogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AF216651; AAF24509.1; -; mRNA.
DR RefSeq; NP_999276.1; NM_214111.1.
DR AlphaFoldDB; Q9TT01; -.
DR SMR; Q9TT01; -.
DR STRING; 9823.ENSSSCP00000005629; -.
DR PaxDb; Q9TT01; -.
DR PRIDE; Q9TT01; -.
DR GeneID; 397199; -.
DR KEGG; ssc:397199; -.
DR CTD; 1761; -.
DR eggNOG; KOG3815; Eukaryota.
DR InParanoid; Q9TT01; -.
DR OrthoDB; 1209937at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0002176; P:male germ cell proliferation; ISS:UniProtKB.
DR GO; GO:0030238; P:male sex determination; ISS:UniProtKB.
DR GO; GO:0046661; P:male sex differentiation; ISS:UniProtKB.
DR GO; GO:0045835; P:negative regulation of meiotic nuclear division; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 3.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW Sexual differentiation; Transcription; Transcription regulation;
KW Tumor suppressor; Zinc.
FT CHAIN 1..373
FT /note="Doublesex- and mab-3-related transcription factor 1"
FT /id="PRO_0000207044"
FT DNA_BIND 67..113
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZ59"
SQ SEQUENCE 373 AA; 39346 MW; 4078ABD9DB90FA3A CRC64;
MPNDDAYSKP SAPSEAPHAP GPPPQGKAGG FSKALLGTSG GGGSGGSSGG GSGASGMSAA
SNKKSPRLPK CARCRNHGYA SPLKGHKRFC MWRDCQCKKC NLIAERQRVM AAQVALRRQQ
AQEEELGISH PIPLPSAAEL LVKRENHGSN PCLMTESSSS SQPPPPPPAA STPTTAAPEG
RMVIQDIPAV TSRGHVENAP DLVSDSTYYS SFYQPSLFPY YNNLYNYPQY SMALAADSSS
GDVGNALGGS PVKNSLRGLP APYVPGQTGN QWQMKNSETR HAVSSQYRMH SYYPPPSYLG
QSVSQIFTFE DGPSYSEAKA SVLSPPSSQD SGLVSLSSSS PISNESTKGV LECESASEPS
SFPVTPVIEE RTK
