ID   DMRT1_XENTR             Reviewed;         337 AA.
AC   P85119; F7DFV8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor 1;
GN   Name=dmrt1 {ECO:0000303|PubMed:17118014};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis {ECO:0000269|PubMed:17118014};
RX   PubMed=17118014; DOI=10.1111/j.1440-169x.2006.00894.x;
RA   Yoshimoto S., Okada E., Oishi T., Numagami R., Umemoto H., Tamura K.,
RA   Kanda H., Shiba T., Takamatsu N., Ito M.;
RT   "Expression and promoter analysis of Xenopus DMRT1 and functional
RT   characterization of the transactivation property of its protein.";
RL   Dev. Growth Differ. 48:597-603(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Transcription factor that plays a key role in male sex
CC       determination and differentiation by controlling testis development and
CC       germ cell proliferation. Acts both as a transcription repressor and
CC       activator (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AAMC01047992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P85119; -.
DR   SMR; P85119; -.
DR   STRING; 8364.ENSXETP00000004858; -.
DR   PaxDb; P85119; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   InParanoid; P85119; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR   GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR022114; DMRT1-like.
DR   PANTHER; PTHR12322; PTHR12322; 3.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF12374; Dmrt1; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..337
FT                   /note="Doublesex- and mab-3-related transcription factor 1"
FT                   /id="PRO_0000284733"
FT   DNA_BIND        32..79
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  36900 MW;  2CF289B5B3F9A578 CRC64;
     MQNNEEPFSK TRSSGQHPSG VHGKKSPRLP KCARCRNHGY ASPLKGHKRF CMWRDCQCKK
     CSLIAERQRV MAAQVALRRQ QAQEEELGIS HPIPLPIAAE LLIKREHGGS SSCLMLESSS
     TQTTSTSTSG STTSSEGKML IQEIPSITSR GHLESTSDLV MDSPYYSNFY QPPLYPYYNN
     LYNYPPYQMA VATESTSGND MGGISGPSMK NSHRNHPAAY VPSQSGNQWQ MKNGENRFPG
     HSASSQFRMH SYYPPYLGQS VPNPVCVPPF LTFEEIPSYS EAKASVALSP PSSQDSGIIS
     LSSNSPVSNE STKGAAEQEP NSESSAFTVT TAGEDRE