DMRT3_HUMAN
ID DMRT3_HUMAN Reviewed; 472 AA.
AC Q9NQL9; Q7LA03; Q7LCH8; Q96SC7; Q9NRQ9;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 3;
GN Name=DMRT3; Synonyms=DMRTA3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 46-169.
RC TISSUE=Testis;
RX PubMed=11863363; DOI=10.1006/geno.2002.6711;
RA Ottolenghi C., Fellous M., Barbieri M., McElreavey K.;
RT "Novel paralogy relations among human chromosomes support a link between
RT the phylogeny of doublesex-related genes and the evolution of sex
RT determination.";
RL Genomics 79:333-343(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 130-472, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=10729223; DOI=10.1006/geno.2000.6121;
RA Ottolenghi C., Veitia R., Quintana-Murci L., Torchard D., Scapoli L.,
RA Souleyreau-Therville N., Beckmann J., Fellous M., McElreavey K.;
RT "The region on 9p associated with 46,XY sex reversal contains several
RT transcripts expressed in the urogenital system and a novel doublesex-
RT related domain.";
RL Genomics 64:170-178(2000).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP INTERACTION WITH UBIQUITIN, AND DOMAIN.
RX PubMed=33021200; DOI=10.7554/elife.59614;
RA Bayer E.A., Stecky R.C., Neal L., Katsamba P.S., Ahlsen G., Balaji V.,
RA Hoppe T., Shapiro L., Oren-Suissa M., Hobert O.;
RT "Ubiquitin-dependent regulation of a conserved DMRT protein controls
RT sexually dimorphic synaptic connectivity and behavior.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: Probable transcription factor that plays a role in
CC configuring the spinal circuits controlling stride in vertebrates.
CC Involved in neuronal specification within specific subdivision of
CC spinal cord neurons and in the development of a coordinated locomotor
CC network controlling limb movements. May regulate transcription during
CC sexual development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: May homodimerize. {ECO:0000269|PubMed:33021200}.
CC -!- INTERACTION:
CC Q9NQL9; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-9679045, EBI-357530;
CC Q9NQL9; Q86U10: ASPG; NbExp=3; IntAct=EBI-9679045, EBI-19946665;
CC Q9NQL9; Q86V38: ATN1; NbExp=3; IntAct=EBI-9679045, EBI-11954292;
CC Q9NQL9; P61421: ATP6V0D1; NbExp=3; IntAct=EBI-9679045, EBI-954063;
CC Q9NQL9; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-9679045, EBI-718615;
CC Q9NQL9; O95273: CCNDBP1; NbExp=3; IntAct=EBI-9679045, EBI-748961;
CC Q9NQL9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9679045, EBI-3867333;
CC Q9NQL9; Q13643: FHL3; NbExp=3; IntAct=EBI-9679045, EBI-741101;
CC Q9NQL9; Q5TD97: FHL5; NbExp=3; IntAct=EBI-9679045, EBI-750641;
CC Q9NQL9; O15353: FOXN1; NbExp=3; IntAct=EBI-9679045, EBI-11319000;
CC Q9NQL9; O43559: FRS3; NbExp=3; IntAct=EBI-9679045, EBI-725515;
CC Q9NQL9; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-9679045, EBI-10261098;
CC Q9NQL9; P28799: GRN; NbExp=3; IntAct=EBI-9679045, EBI-747754;
CC Q9NQL9; O75031: HSF2BP; NbExp=3; IntAct=EBI-9679045, EBI-7116203;
CC Q9NQL9; Q0VD86: INCA1; NbExp=6; IntAct=EBI-9679045, EBI-6509505;
CC Q9NQL9; O75525: KHDRBS3; NbExp=3; IntAct=EBI-9679045, EBI-722504;
CC Q9NQL9; Q5T749: KPRP; NbExp=5; IntAct=EBI-9679045, EBI-10981970;
CC Q9NQL9; Q15323: KRT31; NbExp=6; IntAct=EBI-9679045, EBI-948001;
CC Q9NQL9; O76011: KRT34; NbExp=3; IntAct=EBI-9679045, EBI-1047093;
CC Q9NQL9; Q92764: KRT35; NbExp=3; IntAct=EBI-9679045, EBI-1058674;
CC Q9NQL9; O76013-2: KRT36; NbExp=3; IntAct=EBI-9679045, EBI-11958506;
CC Q9NQL9; O76015: KRT38; NbExp=3; IntAct=EBI-9679045, EBI-1047263;
CC Q9NQL9; Q6A162: KRT40; NbExp=6; IntAct=EBI-9679045, EBI-10171697;
CC Q9NQL9; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-9679045, EBI-11959885;
CC Q9NQL9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-9679045, EBI-11749135;
CC Q9NQL9; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-9679045, EBI-11741292;
CC Q9NQL9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-9679045, EBI-10172290;
CC Q9NQL9; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-9679045, EBI-10171774;
CC Q9NQL9; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-9679045, EBI-10172052;
CC Q9NQL9; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-9679045, EBI-1048945;
CC Q9NQL9; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-9679045, EBI-14065470;
CC Q9NQL9; Q9BYR8: KRTAP3-1; NbExp=5; IntAct=EBI-9679045, EBI-9996449;
CC Q9NQL9; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-9679045, EBI-3957694;
CC Q9NQL9; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-9679045, EBI-11987425;
CC Q9NQL9; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-9679045, EBI-3958099;
CC Q9NQL9; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-9679045, EBI-11962084;
CC Q9NQL9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-9679045, EBI-1044640;
CC Q9NQL9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-9679045, EBI-1043191;
CC Q9NQL9; Q14847-2: LASP1; NbExp=3; IntAct=EBI-9679045, EBI-9088686;
CC Q9NQL9; P25791-3: LMO2; NbExp=3; IntAct=EBI-9679045, EBI-11959475;
CC Q9NQL9; Q99750: MDFI; NbExp=6; IntAct=EBI-9679045, EBI-724076;
CC Q9NQL9; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-9679045, EBI-16439278;
CC Q9NQL9; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-9679045, EBI-10172526;
CC Q9NQL9; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-9679045, EBI-742948;
CC Q9NQL9; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-9679045, EBI-11522433;
CC Q9NQL9; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-9679045, EBI-5662487;
CC Q9NQL9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-9679045, EBI-10271199;
CC Q9NQL9; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-9679045, EBI-12868744;
CC Q9NQL9; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-9679045, EBI-945833;
CC Q9NQL9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-9679045, EBI-22310682;
CC Q9NQL9; O43482: OIP5; NbExp=3; IntAct=EBI-9679045, EBI-536879;
CC Q9NQL9; Q99471: PFDN5; NbExp=3; IntAct=EBI-9679045, EBI-357275;
CC Q9NQL9; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-9679045, EBI-742388;
CC Q9NQL9; O15162: PLSCR1; NbExp=3; IntAct=EBI-9679045, EBI-740019;
CC Q9NQL9; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-9679045, EBI-3957793;
CC Q9NQL9; P86480: PRR20D; NbExp=3; IntAct=EBI-9679045, EBI-12754095;
CC Q9NQL9; P25788: PSMA3; NbExp=3; IntAct=EBI-9679045, EBI-348380;
CC Q9NQL9; P61289: PSME3; NbExp=3; IntAct=EBI-9679045, EBI-355546;
CC Q9NQL9; Q93062: RBPMS; NbExp=3; IntAct=EBI-9679045, EBI-740322;
CC Q9NQL9; Q04864: REL; NbExp=3; IntAct=EBI-9679045, EBI-307352;
CC Q9NQL9; Q04864-2: REL; NbExp=3; IntAct=EBI-9679045, EBI-10829018;
CC Q9NQL9; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-9679045, EBI-746118;
CC Q9NQL9; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-9679045, EBI-6257312;
CC Q9NQL9; P21673: SAT1; NbExp=6; IntAct=EBI-9679045, EBI-711613;
CC Q9NQL9; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-9679045, EBI-11959123;
CC Q9NQL9; P15884: TCF4; NbExp=3; IntAct=EBI-9679045, EBI-533224;
CC Q9NQL9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-9679045, EBI-11741437;
CC Q9NQL9; Q13077: TRAF1; NbExp=3; IntAct=EBI-9679045, EBI-359224;
CC Q9NQL9; P36406: TRIM23; NbExp=3; IntAct=EBI-9679045, EBI-740098;
CC Q9NQL9; P14373: TRIM27; NbExp=6; IntAct=EBI-9679045, EBI-719493;
CC Q9NQL9; Q15654: TRIP6; NbExp=3; IntAct=EBI-9679045, EBI-742327;
CC Q9NQL9; Q86WV8: TSC1; NbExp=3; IntAct=EBI-9679045, EBI-12806590;
CC Q9NQL9; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-9679045, EBI-948354;
CC Q9NQL9; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-9679045, EBI-1380492;
CC Q9NQL9; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-9679045, EBI-11975223;
CC Q9NQL9; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-9679045, EBI-12040603;
CC Q9NQL9; P08048: ZFY; NbExp=3; IntAct=EBI-9679045, EBI-12239601;
CC Q9NQL9; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-9679045, EBI-12030590;
CC Q9NQL9; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-9679045, EBI-11962468;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:10729223}.
CC -!- DEVELOPMENTAL STAGE: Expressed in 4 to 5 weeks embryos.
CC {ECO:0000269|PubMed:10729223}.
CC -!- DOMAIN: DMA domain interacts with ubiquitin.
CC {ECO:0000269|PubMed:33021200}.
CC -!- MISCELLANEOUS: DMRT3 is a marker for a subset of spinal cord neurons
CC (dI6).
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=A gait on the wildside
CC - Issue 154 of November 2013;
CC URL="https://web.expasy.org/spotlight/back_issues/154/";
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DR EMBL; AL136365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113584; AAI13585.1; -; mRNA.
DR EMBL; BC117245; AAI17246.1; -; mRNA.
DR EMBL; AJ301581; CAC37947.1; -; mRNA.
DR EMBL; AF193873; AAF78892.1; -; mRNA.
DR CCDS; CCDS6443.1; -.
DR RefSeq; NP_067063.1; NM_021240.3.
DR AlphaFoldDB; Q9NQL9; -.
DR SMR; Q9NQL9; -.
DR BioGRID; 121844; 86.
DR IntAct; Q9NQL9; 79.
DR MINT; Q9NQL9; -.
DR STRING; 9606.ENSP00000190165; -.
DR iPTMnet; Q9NQL9; -.
DR PhosphoSitePlus; Q9NQL9; -.
DR BioMuta; DMRT3; -.
DR DMDM; 74752905; -.
DR MassIVE; Q9NQL9; -.
DR PaxDb; Q9NQL9; -.
DR PeptideAtlas; Q9NQL9; -.
DR PRIDE; Q9NQL9; -.
DR ProteomicsDB; 82163; -.
DR Antibodypedia; 23783; 164 antibodies from 23 providers.
DR DNASU; 58524; -.
DR Ensembl; ENST00000190165.3; ENSP00000190165.2; ENSG00000064218.5.
DR GeneID; 58524; -.
DR KEGG; hsa:58524; -.
DR MANE-Select; ENST00000190165.3; ENSP00000190165.2; NM_021240.4; NP_067063.1.
DR UCSC; uc003zgw.3; human.
DR CTD; 58524; -.
DR DisGeNET; 58524; -.
DR GeneCards; DMRT3; -.
DR HGNC; HGNC:13909; DMRT3.
DR HPA; ENSG00000064218; Tissue enhanced (choroid plexus, parathyroid gland, testis).
DR MalaCards; DMRT3; -.
DR MIM; 614754; gene.
DR neXtProt; NX_Q9NQL9; -.
DR OpenTargets; ENSG00000064218; -.
DR Orphanet; 251510; 46,XY partial gonadal dysgenesis.
DR PharmGKB; PA27383; -.
DR VEuPathDB; HostDB:ENSG00000064218; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000160420; -.
DR HOGENOM; CLU_052449_1_0_1; -.
DR InParanoid; Q9NQL9; -.
DR OMA; RWASEPQ; -.
DR OrthoDB; 897429at2759; -.
DR PhylomeDB; Q9NQL9; -.
DR TreeFam; TF317837; -.
DR PathwayCommons; Q9NQL9; -.
DR SignaLink; Q9NQL9; -.
DR BioGRID-ORCS; 58524; 9 hits in 1086 CRISPR screens.
DR ChiTaRS; DMRT3; human.
DR GenomeRNAi; 58524; -.
DR Pharos; Q9NQL9; Tbio.
DR PRO; PR:Q9NQL9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9NQL9; protein.
DR Bgee; ENSG00000064218; Expressed in mucosa of paranasal sinus and 75 other tissues.
DR ExpressionAtlas; Q9NQL9; baseline and differential.
DR Genevisible; Q9NQL9; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0046661; P:male sex differentiation; IBA:GO_Central.
DR GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Sexual differentiation; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..472
FT /note="Doublesex- and mab-3-related transcription factor 3"
FT /id="PRO_0000277794"
FT DOMAIN 249..284
FT /note="DMA"
FT /evidence="ECO:0000255"
FT DNA_BIND 29..76
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 89..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..122
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 164
FT /note="A -> T (in dbSNP:rs10978001)"
FT /id="VAR_030591"
FT VARIANT 261
FT /note="N -> T (in dbSNP:rs7854621)"
FT /id="VAR_030592"
FT VARIANT 356
FT /note="G -> V (in dbSNP:rs16927037)"
FT /id="VAR_030593"
SQ SEQUENCE 472 AA; 51199 MW; BD76C5BE0B100A50 CRC64;
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL
IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAVAAPQPP PASQPSQPQP
PRPAAELAAA AALRWTAEPQ PGALQAQLAK PDLTEERLGD GKSADNTEVF SDKDTDQRSS
PDVAKSKGCF TPESPEIVSV EEGGYAVQKN GGNPESRPDS PKCHAEQNHL LIEGPSGTVS
LPFSLKANRP PLEVLKKIFP NQKPTVLELI LKGCGGDLVS AVEVLLSSRS SVTGAERTSA
EPESLALPSN GHIFEHTLSS YPISSSKWSV GSAFRVPDTL RFSADSSNVV PSPLAGPLQP
PFPQPPRYPL MLRNTLARSQ SSPFLPNDVT LWNTMTLQQQ YQLRSQYVSP FPSNSTSVFR
SSPVLPARAT EDPRISIPDD GCPFVSKQSI YTEDDYDERS DSSDSRTLNT SS
