ID   DMRT3_RAT               Reviewed;         476 AA.
AC   D4A218;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Doublesex and mab-3 related transcription factor 3;
GN   Name=Dmrt3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor that plays a role in
CC       configuring the spinal circuits controlling stride in vertebrates.
CC       Involved in neuronal specification within a specific subdivision of
CC       spinal cord neurons and in the development of a coordinated locomotor
CC       network controlling limb movements. May regulate transcription during
CC       sexual development (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- DOMAIN: DMA domain interacts with ubiquitin.
CC       {ECO:0000250|UniProtKB:Q9NQL9}.
CC   -!- MISCELLANEOUS: DMRT3 is a marker for a subset of spinal cord neurons
CC       (dI6).
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AABR06010381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06010382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473953; EDM13051.1; -; Genomic_DNA.
DR   RefSeq; NP_001099828.1; NM_001106358.1.
DR   AlphaFoldDB; D4A218; -.
DR   SMR; D4A218; -.
DR   STRING; 10116.ENSRNOP00000021792; -.
DR   iPTMnet; D4A218; -.
DR   PhosphoSitePlus; D4A218; -.
DR   PaxDb; D4A218; -.
DR   Ensembl; ENSRNOT00000021792; ENSRNOP00000021792; ENSRNOG00000016284.
DR   GeneID; 293976; -.
DR   KEGG; rno:293976; -.
DR   UCSC; RGD:1306043; rat.
DR   CTD; 58524; -.
DR   RGD; 1306043; Dmrt3.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00940000160420; -.
DR   HOGENOM; CLU_052449_1_0_1; -.
DR   InParanoid; D4A218; -.
DR   OMA; RWASEPQ; -.
DR   OrthoDB; 897429at2759; -.
DR   PhylomeDB; D4A218; -.
DR   TreeFam; TF317837; -.
DR   PRO; PR:D4A218; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000016284; Expressed in testis.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR   GO; GO:0046661; P:male sex differentiation; ISO:RGD.
DR   GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   GO; GO:0019226; P:transmission of nerve impulse; ISO:RGD.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; ISO:RGD.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Sexual differentiation; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..476
FT                   /note="Doublesex and mab-3 related transcription factor 3"
FT                   /id="PRO_0000422703"
FT   DOMAIN          255..290
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        29..76
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          89..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  51444 MW;  22A50D71DB1A1071 CRC64;
     MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL
     IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAAATAATA SQSSPASQAS
     QPPAPPRPAT ELAAAAALRW VAEPQPGTLP AQIAKPDLTE DRLGDSSSAD NAAESFSDKD
     TDQRSSPDVV KSKNCFTPES PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG
     PSGTVSLPFS LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG
     AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS SNVVPNPLAV
     PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT LQQQYQLRSQ YVSPFPSNST
     SVFRSSPVLS SRTTEDPRIS IPDDGCPIVA KQSIYTEDDY DERSDSSDSR ILNTSS