DMRTA_MOUSE
ID DMRTA_MOUSE Reviewed; 490 AA.
AC Q8CFG4; A2AL09;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Doublesex- and mab-3-related transcription factor A1;
DE AltName: Full=Doublesex- and mab-3-related transcription factor 4;
GN Name=Dmrta1; Synonyms=Dmrt4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Spinal ganglion;
RX PubMed=12609607; DOI=10.1016/s1567-133x(02)00071-6;
RA Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
RT "Sexually dimorphic expression of multiple doublesex-related genes in the
RT embryonic mouse gonad.";
RL Gene Expr. Patterns 3:77-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=16982677; DOI=10.1128/mcb.00959-06;
RA Balciuniene J., Bardwell V.J., Zarkower D.;
RT "Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have
RT polyovular follicles.";
RL Mol. Cell. Biol. 26:8984-8991(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in ovary,
CC testis, epididymis, preputial gland, vomeronasal organ, liver, salivary
CC glands and heart. Also expressed throughout the brain with highest
CC levels in the olfactory bulbs and medulla. Detected at similar levels
CC in gonads of both sexes. {ECO:0000269|PubMed:12609607,
CC ECO:0000269|PubMed:16982677}.
CC -!- DEVELOPMENTAL STAGE: Expressed in gonads from 11.5 dpc onward.
CC Expressed in the genital ridge at 11.5 dpc and in the seminiferous
CC tubules at 12.5 dpc. {ECO:0000269|PubMed:12609607}.
CC -!- DISRUPTION PHENOTYPE: Mutant animals are viable and fertile, with no
CC obvious anatomical defects. Ovaries from mutant females may have an
CC elevated number of polyovular follicles. 25% of mutant males
CC consistently exhibit copulatory behavior toward other males.
CC {ECO:0000269|PubMed:16982677}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AF542047; AAN77234.1; -; mRNA.
DR EMBL; AL772403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18352.1; -.
DR RefSeq; NP_783578.1; NM_175647.3.
DR AlphaFoldDB; Q8CFG4; -.
DR SMR; Q8CFG4; -.
DR STRING; 10090.ENSMUSP00000057488; -.
DR iPTMnet; Q8CFG4; -.
DR PhosphoSitePlus; Q8CFG4; -.
DR PaxDb; Q8CFG4; -.
DR PRIDE; Q8CFG4; -.
DR ProteomicsDB; 279734; -.
DR Antibodypedia; 24917; 149 antibodies from 27 providers.
DR DNASU; 242523; -.
DR Ensembl; ENSMUST00000052478; ENSMUSP00000057488; ENSMUSG00000043753.
DR GeneID; 242523; -.
DR KEGG; mmu:242523; -.
DR UCSC; uc008tol.1; mouse.
DR CTD; 63951; -.
DR MGI; MGI:2653627; Dmrta1.
DR VEuPathDB; HostDB:ENSMUSG00000043753; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000160640; -.
DR HOGENOM; CLU_038477_1_0_1; -.
DR InParanoid; Q8CFG4; -.
DR OMA; FYNGFMG; -.
DR OrthoDB; 1573364at2759; -.
DR PhylomeDB; Q8CFG4; -.
DR TreeFam; TF317837; -.
DR BioGRID-ORCS; 242523; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8CFG4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8CFG4; protein.
DR Bgee; ENSMUSG00000043753; Expressed in otolith organ and 64 other tissues.
DR Genevisible; Q8CFG4; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0060179; P:male mating behavior; IMP:MGI.
DR GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..490
FT /note="Doublesex- and mab-3-related transcription factor
FT A1"
FT /id="PRO_0000242701"
FT DOMAIN 314..349
FT /note="DMA"
FT /evidence="ECO:0000255"
FT DNA_BIND 86..133
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 52653 MW; EF52FF88E2D39D0E CRC64;
MERLPHGRRD RSGGCRPHLA PGRAAAPASA ARSVSSGIPV SATFLRPPGL FLRSTASSGR
AGCAPGPGLD RALGAVGCGY PRTPKCARCR NHGVVSALKG HKRFCRWRDC ACAKCTLIAE
RQRVMAAQVA LRRQQAQEES EARGLHRLLY QGSSGSGAQA SGGSGRTESP QVLNNPMAVA
VLGAGASRHP GSRSVPTFEV FQQDYADRKQ EPKQRNCESC QSRQEEPVSN THHHSLGSSK
GNVTVEKQGF MSSIPEHPDK STIILSPCPT DQSGGEDSPR SFSSSDLESG NESEWARDYI
ATRASLSTVT SRPRDPLGIL TRIFPGYKHS RLEGILQFCK GDVVQAIEQI LNGREHKPDC
RDLARADLEN AAFQRASDFS LAGIGFGTLS NKSALSPLEA ASAAYGGDST LYSFNPRLAF
SPLRLAYSSP GRALSGFVSP YLTPGLVPAL PFRPTLDYAF PGMIREPSHL PSKHLVAGGR
LYFRPNQEHL
