DMRTB_MOUSE
ID DMRTB_MOUSE Reviewed; 359 AA.
AC A2A9I7; Q8CGW8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Doublesex- and mab-3-related transcription factor B1;
DE AltName: Full=Doublesex- and mab-3-related transcription factor 6;
GN Name=Dmrtb1; Synonyms=Dmrt6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-257, AND TISSUE SPECIFICITY.
RX PubMed=12609607; DOI=10.1016/s1567-133x(02)00071-6;
RA Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
RT "Sexually dimorphic expression of multiple doublesex-related genes in the
RT embryonic mouse gonad.";
RL Gene Expr. Patterns 3:77-82(2003).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Brain. {ECO:0000269|PubMed:12609607}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AL627259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF542048; AAN77235.1; -; mRNA.
DR CCDS; CCDS51254.1; -.
DR RefSeq; NP_063925.1; NM_019872.1.
DR AlphaFoldDB; A2A9I7; -.
DR SMR; A2A9I7; -.
DR STRING; 10090.ENSMUSP00000064220; -.
DR PhosphoSitePlus; A2A9I7; -.
DR PaxDb; A2A9I7; -.
DR PeptideAtlas; A2A9I7; -.
DR PRIDE; A2A9I7; -.
DR ProteomicsDB; 279440; -.
DR Antibodypedia; 19214; 94 antibodies from 21 providers.
DR Ensembl; ENSMUST00000069271; ENSMUSP00000064220; ENSMUSG00000028610.
DR GeneID; 56296; -.
DR KEGG; mmu:56296; -.
DR UCSC; uc008tzy.2; mouse.
DR CTD; 63948; -.
DR MGI; MGI:1927125; Dmrtb1.
DR VEuPathDB; HostDB:ENSMUSG00000028610; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000161912; -.
DR HOGENOM; CLU_073336_0_0_1; -.
DR InParanoid; A2A9I7; -.
DR OMA; KQCICDK; -.
DR OrthoDB; 1042183at2759; -.
DR PhylomeDB; A2A9I7; -.
DR TreeFam; TF317837; -.
DR BioGRID-ORCS; 56296; 8 hits in 72 CRISPR screens.
DR ChiTaRS; Dmrtb1; mouse.
DR PRO; PR:A2A9I7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2A9I7; protein.
DR Bgee; ENSMUSG00000028610; Expressed in seminiferous tubule of testis and 54 other tissues.
DR ExpressionAtlas; A2A9I7; baseline and differential.
DR Genevisible; A2A9I7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..359
FT /note="Doublesex- and mab-3-related transcription factor
FT B1"
FT /id="PRO_0000316013"
FT DNA_BIND 7..54
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 111..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..303
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 38424 MW; 524DC00CDC24A543 CRC64;
MLRAPKCSRC RNHGYLVPVK GHTGKCRWKQ CICDKCYLIT ERQKIMAAQK VLRTQAAEEQ
VATVGTQGPQ LPPRAPAAAA TALSSSICPL PRAVPGGVGP GPTATCFLER PPQAPSPGPS
TFQLGPSGRP GPSTFQPGPG APGGLRDRSS AWLPQLMPQA PRPELCYPDQ HLPVRPVPVP
GPVRPVPRLP FADYGHPLRF KSDHVVGAGN PEREPFKQCP ACVPVSPYQS FPLSEGQDSS
SALGVPQQRG FRHVSCSPYH RSGLVSEPAR DLQPTYCSPP PPPPPPPPPP LPAPPPQPQQ
PHFLPPGYLS ALHFLPPPPP PPSPPSFSLT YDTDKENTND QDAEAPTEPS QDSPQEQSN
