DMRTD_MOUSE
ID DMRTD_MOUSE Reviewed; 370 AA.
AC Q8CGW9; A6H6T0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Doublesex- and mab-3-related transcription factor C2;
DE AltName: Full=Doublesex- and mab-3-related transcription factor 7;
GN Name=Dmrtc2; Synonyms=Dmrt7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=12609607; DOI=10.1016/s1567-133x(02)00071-6;
RA Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
RT "Sexually dimorphic expression of multiple doublesex-related genes in the
RT embryonic mouse gonad.";
RL Gene Expr. Patterns 3:77-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in sexual development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. Highly expressed in ovary.
CC -!- DEVELOPMENTAL STAGE: Expressed in gonads from 11.5 dpc.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF542046; AAN77233.1; -; mRNA.
DR EMBL; BC100434; AAI00435.1; -; mRNA.
DR EMBL; BC138203; AAI38204.1; -; mRNA.
DR EMBL; BC145988; AAI45989.1; -; mRNA.
DR CCDS; CCDS20965.1; -.
DR RefSeq; NP_082008.1; NM_027732.2.
DR RefSeq; XP_006540422.1; XM_006540359.3.
DR AlphaFoldDB; Q8CGW9; -.
DR SMR; Q8CGW9; -.
DR BioGRID; 214575; 8.
DR IntAct; Q8CGW9; 8.
DR STRING; 10090.ENSMUSP00000011493; -.
DR PhosphoSitePlus; Q8CGW9; -.
DR PaxDb; Q8CGW9; -.
DR PRIDE; Q8CGW9; -.
DR ProteomicsDB; 279389; -.
DR Antibodypedia; 30826; 133 antibodies from 22 providers.
DR DNASU; 71241; -.
DR Ensembl; ENSMUST00000011493; ENSMUSP00000011493; ENSMUSG00000011349.
DR GeneID; 71241; -.
DR KEGG; mmu:71241; -.
DR UCSC; uc009fqp.2; mouse.
DR CTD; 63946; -.
DR MGI; MGI:1918491; Dmrtc2.
DR VEuPathDB; HostDB:ENSMUSG00000011349; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000161904; -.
DR HOGENOM; CLU_050863_1_0_1; -.
DR InParanoid; Q8CGW9; -.
DR OMA; PLPWTPM; -.
DR OrthoDB; 897429at2759; -.
DR PhylomeDB; Q8CGW9; -.
DR TreeFam; TF340713; -.
DR BioGRID-ORCS; 71241; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Dmrtc2; mouse.
DR PRO; PR:Q8CGW9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CGW9; protein.
DR Bgee; ENSMUSG00000011349; Expressed in seminiferous tubule of testis and 15 other tissues.
DR Genevisible; Q8CGW9; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001741; C:XY body; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0036123; P:histone H3-K9 dimethylation; IMP:MGI.
DR GO; GO:0036124; P:histone H3-K9 trimethylation; IMP:MGI.
DR GO; GO:0007141; P:male meiosis I; IMP:MGI.
DR GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; IMP:MGI.
DR GO; GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR GO; GO:0007290; P:spermatid nucleus elongation; IMP:MGI.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR031577; DMRT-C1/C2_C.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF15791; DMRT-like; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..370
FT /note="Doublesex- and mab-3-related transcription factor
FT C2"
FT /id="PRO_0000244107"
FT DNA_BIND 42..89
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 39095 MW; F4DFCB23C94C8A6C CRC64;
MDPSETAALH HCSADSSPAD EARVPQSTEL IPRRPVSRSP TCARCRNHGV TAHLKGHKRL
CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKRHLA QGLMKGATPL KAPLRVKKGA
IRPGIPSGKE NIAPQPQSPH GAVPLVLTPP GKENYGPLLL SRPPEALPLP WTPVPPGPWG
PGHWLPPGLS MPPPVVCRLL CQEPAVPLHP FPGFDPGTSL RLPTHGTLPT CPGSRSVLTA
PLSGEPQGPP NLPHTCSTLI LQSCGTPDSL LLQPQAPGAS CLAWTSGPSE RQLQREAAEA
LVGLKDSSQA PRLTPSVPPN PAWISLLHPC GPPAPPGGRG FQPVGPPLRP SPGSSVSLHI
GRLGSISLLS
