ID   DMS6_PITAZ              Reviewed;          29 AA.
AC   P84936;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Dermaseptin-H6 {ECO:0000303|PubMed:17553595};
DE   AltName: Full=Dermaseptin-H1;
DE   AltName: Full=Dermaseptin-like peptide 1;
DE            Short=DMS1;
DE   AltName: Full=Dermaseptin-like peptide 6 {ECO:0000303|PubMed:17553595};
DE            Short=DMS6 {ECO:0000303|PubMed:17553595};
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-29.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:17553595};
RX   PubMed=17553595; DOI=10.1016/j.peptides.2007.05.001;
RA   Thompson A.H., Bjourson A.J., Orr D.F., Shaw C., McClean S.;
RT   "A combined mass spectrometric and cDNA sequencing approach to the
RT   isolation and characterization of novel antimicrobial peptides from the
RT   skin secretions of Phyllomedusa hypochondrialis azurea.";
RL   Peptides 28:1331-1343(2007).
CC   -!- FUNCTION: Possesses a potent antimicrobial activity against Gram-
CC       positive and Gram-negative bacteria. Probably acts by disturbing
CC       membrane functions with its amphipathic structure (By similarity).
CC       {ECO:0000250|UniProtKB:P80281}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17553595}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:17553595}.
CC   -!- MASS SPECTROMETRY: Mass=2793.01; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17553595};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P84936; -.
DR   SMR; P84936; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Dermaseptin-H6"
FT                   /evidence="ECO:0000269|PubMed:17553595"
FT                   /id="PRO_0000250576"
FT   MOD_RES         29
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:17553595"
SQ   SEQUENCE   29 AA;  2795 MW;  B2B596776E2074C6 CRC64;
     GLWSTIKQKG KEAAIAAAKA AGQAALGAL