ID   DMS8_PHYBU              Reviewed;          33 AA.
AC   P86280;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Dermaseptin DS VIII-like peptide {ECO:0000303|Ref.1};
OS   Phyllomedusa burmeisteri (Brazilian common walking leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=39413;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT ALA-33.
RC   TISSUE=Parotoid gland secretion {ECO:0000269|Ref.1};
RA   Conceicao K., Klitzke C.F., Brito R.C., Andrade D.F., Junca F.A.,
RA   Biondi I., Lopes-Ferreira M.;
RT   "Identification of peptides from Phyllomedusa burmesteri skin secretomics
RT   by nano LC MS/MS.";
RL   Submitted (APR-2009) to UniProtKB.
CC   -!- FUNCTION: Possesses a potent antimicrobial activity against bacteria,
CC       fungi and protozoa. Probably acts by disturbing membrane functions with
CC       its amphipathic structure (By similarity).
CC       {ECO:0000250|UniProtKB:P24302}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the parotoid glands.
CC       {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=3261.91; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P86280; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Dermaseptin DS VIII-like peptide"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000378911"
FT   MOD_RES         33
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   33 AA;  3265 MW;  F4BBCD5BBD2F50F8 CRC64;
     ALWKTMLKKL GTVALHAGKA ALGAAADTIS QGA