DMSR_HALSA
ID DMSR_HALSA Reviewed; 224 AA.
AC Q9HR76;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Dimethyl sulfoxide reductase transcriptional activator;
DE Short=DMSO reductase transcriptional activator;
GN Name=dmsR; OrderedLocusNames=VNG_0826C;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=15716436; DOI=10.1128/jb.187.5.1659-1667.2005;
RA Muller J.A., DasSarma S.;
RT "Genomic analysis of anaerobic respiration in the archaeon Halobacterium
RT sp. strain NRC-1: dimethyl sulfoxide and trimethylamine N-oxide as terminal
RT electron acceptors.";
RL J. Bacteriol. 187:1659-1667(2005).
CC -!- FUNCTION: Involved in activating dmsEABCD gene expression related to
CC dimethyl sulfoxide (DMSO) reductase. Required for anaerobic respiration
CC on dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO).
CC {ECO:0000269|PubMed:15716436}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene displayed a marked
CC decrease in growth under anaerobic conditions using either DMSO or TMAO
CC as terminal electron acceptors. {ECO:0000269|PubMed:15716436}.
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DR EMBL; AE004437; AAG19282.1; -; Genomic_DNA.
DR PIR; F84239; F84239.
DR RefSeq; WP_010902578.1; NC_002607.1.
DR AlphaFoldDB; Q9HR76; -.
DR STRING; 64091.VNG_0826C; -.
DR PaxDb; Q9HR76; -.
DR EnsemblBacteria; AAG19282; AAG19282; VNG_0826C.
DR GeneID; 5953987; -.
DR GeneID; 62884249; -.
DR KEGG; hal:VNG_0826C; -.
DR PATRIC; fig|64091.14.peg.635; -.
DR HOGENOM; CLU_109670_1_0_2; -.
DR OMA; AFSEVGC; -.
DR OrthoDB; 70649at2157; -.
DR PhylomeDB; Q9HR76; -.
DR Proteomes; UP000000554; Chromosome.
DR InterPro; IPR007050; HTH_bacterioopsin.
DR Pfam; PF04967; HTH_10; 1.
PE 4: Predicted;
KW Activator; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..224
FT /note="Dimethyl sulfoxide reductase transcriptional
FT activator"
FT /id="PRO_0000428979"
FT DOMAIN 158..209
FT /note="HTH bat-type"
FT /evidence="ECO:0000255"
SQ SEQUENCE 224 AA; 23608 MW; 2996D5822C29A979 CRC64;
MSERTASQPN TDRSRRRLRV VLDVALSDAA ACPLEEIDGE VTAVRHQYTG DDCHADVTVA
PACPDDDRSD VMHVATQTTD SCLCCVFSDH GCVPQITAVA ADTITVETYL ADRTTLTDLV
ADLKAVANTV SLTHLTRLAA DDQSGDSHTH VTLDLFKLTD KQREAAAAAV AKGYYATPRG
ADLSDLATAL GISKSAVSQR LSAVESKLAT SAFTEAQQSA GSAP