DMT1A_XENLA
ID DMT1A_XENLA Reviewed; 336 AA.
AC Q3LH63; A4PBN6; B7ZPD0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 1A;
DE Short=xDmrt1;
DE AltName: Full=DMRT1-alpha;
GN Name=dmrt1-a; Synonyms=dmrt1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE45870.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15988164; DOI=10.2108/zsj.22.681;
RA Osawa N., Oshima Y., Nakamura M.;
RT "Molecular cloning of Dmrt1 and its expression in the gonad of Xenopus.";
RL Zool. Sci. 22:681-687(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Gonad {ECO:0000269|PubMed:17118014};
RX PubMed=17118014; DOI=10.1111/j.1440-169x.2006.00894.x;
RA Yoshimoto S., Okada E., Oishi T., Numagami R., Umemoto H., Tamura K.,
RA Kanda H., Shiba T., Takamatsu N., Ito M.;
RT "Expression and promoter analysis of Xenopus DMRT1 and functional
RT characterization of the transactivation property of its protein.";
RL Dev. Growth Differ. 48:597-603(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=18268317; DOI=10.1073/pnas.0712244105;
RA Yoshimoto S., Okada E., Umemoto H., Tamura K., Uno Y., Nishida-Umehara C.,
RA Matsuda Y., Takamatsu N., Shiba T., Ito M.;
RT "A W-linked DM-domain gene, DM-W, participates in primary ovary development
RT in Xenopus laevis.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2469-2474(2008).
RN [5]
RP FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
RX PubMed=20573695; DOI=10.1242/dev.048751;
RA Yoshimoto S., Ikeda N., Izutsu Y., Shiba T., Takamatsu N., Ito M.;
RT "Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual
RT dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-determining
RT system.";
RL Development 137:2519-2526(2010).
CC -!- FUNCTION: Transcription factor that plays a key role in male sex
CC determination and differentiation by controlling testis development and
CC germ cell proliferation. Acts both as a transcription repressor and
CC activator. {ECO:0000269|PubMed:17118014, ECO:0000269|PubMed:20573695}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the embryo during early
CC development, becoming restricted to the primordial gonads in stage 52
CC tadpoles. Expressed exclusively in the primordial gonads of both ZW and
CC ZZ tadpoles. Specifically expressed in the somatic cells surrounding
CC primordial germ cells in gonad at stage 50 during sex determination in
CC ZZ and ZW tadpoles (at protein level). {ECO:0000269|PubMed:15988164,
CC ECO:0000269|PubMed:17118014, ECO:0000269|PubMed:20573695}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expression in maintained in the ZW and ZZ gonads.
CC {ECO:0000269|PubMed:15988164, ECO:0000269|PubMed:17118014,
CC ECO:0000269|PubMed:18268317}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AB201112; BAE45870.1; -; mRNA.
DR EMBL; AB252634; BAF51968.1; -; mRNA.
DR EMBL; BC169409; AAI69409.1; -; mRNA.
DR EMBL; BC169413; AAI69413.1; -; mRNA.
DR RefSeq; NP_001089969.1; NM_001096500.1.
DR AlphaFoldDB; Q3LH63; -.
DR SMR; Q3LH63; -.
DR GeneID; 735040; -.
DR KEGG; xla:735040; -.
DR CTD; 735040; -.
DR Xenbase; XB-GENE-864801; dmrt1.L.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 735040; Expressed in testis and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008584; P:male gonad development; IMP:UniProtKB.
DR GO; GO:0030238; P:male sex determination; IMP:UniProtKB.
DR GO; GO:0046661; P:male sex differentiation; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 3.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Repressor;
KW Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..336
FT /note="Doublesex- and mab-3-related transcription factor
FT 1A"
FT /id="PRO_0000284732"
FT DNA_BIND 32..79
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 36999 MW; 6D1951009B151C85 CRC64;
MQNNEEPYSK TRNSGQHPSG VHTKKSPRLP KCARCRNHGY ASPLKGHKRY CMWRDCQCKK
CSLIAERQRV MAAQVALRRQ QAQEEELGIS HPIHLPIAAE LLIKKEHGGS SSCLMLENSS
TQTTSTPTSG STASSEGKVL IQEIPSITSR GHMESTSDLV MDSPYYSNFY QPPLYPYYNN
LYNYPPYQMA MAAESTSGND MGGISGPPLK NNHRNHPAAY VPSQSGNQWQ MKNRENRFPG
HSGSSQFRMH SYYPPYLGQS VPNPACVPPF LTFEEIPSYS EAKASVLSPP SSQDSGVISL
SSNSPVSNES TKAVAEQEPN SESSLFTVTT AAENGE
