ID   DMT1B_XENLA             Reviewed;         336 AA.
AC   B7ZS42; A4PBN7; B7ZS44;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor 1B;
DE   AltName: Full=DMRT1-beta;
GN   Name=dmrt1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Osawa N., Nakamura M.;
RT   "Molecular cloning of Dmrt1 variants in Xenopus.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that plays a key role in male sex
CC       determination and differentiation by controlling testis development and
CC       germ cell proliferation. Acts both as a transcription repressor and
CC       activator (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AB252635; BAF51969.1; -; mRNA.
DR   EMBL; BC170389; AAI70389.1; -; mRNA.
DR   EMBL; BC170391; AAI70391.1; -; mRNA.
DR   RefSeq; NP_001078952.1; NM_001085483.1.
DR   AlphaFoldDB; B7ZS42; -.
DR   SMR; B7ZS42; -.
DR   GeneID; 100048915; -.
DR   KEGG; xla:100048915; -.
DR   CTD; 100048915; -.
DR   Xenbase; XB-GENE-6255833; dmrt1.S.
DR   OrthoDB; 1209937at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 100048915; Expressed in testis and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR022114; DMRT1-like.
DR   PANTHER; PTHR12322; PTHR12322; 2.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF12374; Dmrt1; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..336
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   1B"
FT                   /id="PRO_0000416903"
FT   DNA_BIND        32..79
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        18
FT                   /note="P -> Q (in Ref. 2; AAI70391)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="V -> A (in Ref. 2; AAI70391)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        133
FT                   /note="T -> N (in Ref. 1; BAF51969)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  36806 MW;  BE19D9F11A6AD52E CRC64;
     MQNNEETYSK TRSTGQHPSG VHGKKSPRLP KCARCRNHGY ASPLKGHKRF CMWRDCQCKK
     CSLIAERQRV MAAQVALRRQ QAQEEELGIS HPIPLPIAAE LLIKREHGGS SSCLMLESSS
     TQTTSTPTSG STTSSDGKML IQDIPSITSR GHMESTSELV MDSPYYSNFY QPPLYPYYNN
     LYNYPPYQMA MTAESTSGND MGGISGPPMK SSHRNHPAAY VPSQSGNQWQ MKNGDNRFSG
     HSTSSQFRMH SYYSPYLGQS VPNPACVPSF LTFEEIPSYS EAKASVLSPP SSQDSGIISL
     CSNSPVSNES TKAVAKQEPN SESSAFTITA AAEDGE