DMT1Y_ORYLA
ID DMT1Y_ORYLA Reviewed; 267 AA.
AC Q8JIR6; Q8AY26;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Doublesex- and mab-3-related transcription factor 1Y;
DE AltName: Full=Y-linked doublesex- and mab-3-related transcription factor;
DE AltName: Full=Y-specific doublesex- and mab-3-related transcription factor;
DE Short=DMY;
GN Name=dmrt1y; Synonyms=dmy;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=HNI;
RX PubMed=12037570; DOI=10.1038/nature751;
RA Matsuda M., Nagahama Y., Shinomiya A., Sato T., Matsuda C., Kobayashi T.,
RA Morrey C.E., Shibata N., Asakawa S., Shimizu N., Hori H., Hamaguchi S.,
RA Sakaizumi M.;
RT "DMY is a Y-specific DM-domain gene required for male development in the
RT medaka fish.";
RL Nature 417:559-563(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=HNI;
RX PubMed=12193652; DOI=10.1073/pnas.182314699;
RA Nanda I., Kondo M., Hornung U., Asakawa S., Winkler C., Shimizu A.,
RA Shan Z., Haaf T., Shimizu N., Shima A., Schmid M., Schartl M.;
RT "A duplicated copy of DMRT1 in the sex-determining region of the Y
RT chromosome of the medaka, Oryzias latipes.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11778-11783(2002).
CC -!- FUNCTION: Transcription factor that plays a key role in male sex
CC determination and differentiation by controlling testis development and
CC germ cell proliferation. Acts both as a transcription repressor and
CC activator. {ECO:0000269|PubMed:12037570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- TISSUE SPECIFICITY: Testis-specific. Localizes to Sertoli cells.
CC {ECO:0000269|PubMed:12193652}.
CC -!- DEVELOPMENTAL STAGE: Expression starts at the neurula stage and
CC persists during embryogenesis and larval stages until adulthood. At
CC hatching and 5 days after hatching, present in XY embryos, but not in
CC XX embryos. Detected only in the somatic cells surrounding germ cells
CC in XY embryos. {ECO:0000269|PubMed:12037570}.
CC -!- DISRUPTION PHENOTYPE: Feminization of XY offsprings.
CC {ECO:0000269|PubMed:12037570}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AB071534; BAB92012.1; -; mRNA.
DR EMBL; AY129240; AAN05398.1; -; mRNA.
DR EMBL; AY129241; AAN05399.1; -; Genomic_DNA.
DR RefSeq; NP_001098150.1; NM_001104680.1.
DR AlphaFoldDB; Q8JIR6; -.
DR SMR; Q8JIR6; -.
DR GeneID; 101161472; -.
DR CTD; 1761; -.
DR InParanoid; Q8JIR6; -.
DR OrthoDB; 1209937at2759; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR GO; GO:0030238; P:male sex determination; IMP:UniProtKB.
DR GO; GO:0046661; P:male sex differentiation; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR022114; DMRT1-like.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF12374; Dmrt1; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Repressor;
KW Sexual differentiation; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..267
FT /note="Doublesex- and mab-3-related transcription factor
FT 1Y"
FT /id="PRO_0000416901"
FT DNA_BIND 16..63
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 98..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 23
FT /note="S -> G (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 41..50
FT /note="HCLKCKLIVD -> QCFKCEQIMV (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="L -> D (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 105..110
FT /note="PAPPPN -> LAIPPS (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="V -> A (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="S -> G (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 141..142
FT /note="QP -> CL (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="Y -> H (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="A -> T (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="G -> D (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="K -> R (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
FT CONFLICT 262..267
FT /note="SSRPTP -> VFPADSMSSETK (in Ref. 2; AAN05398)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 267 AA; 29299 MW; CAB91367AEF48FB7 CRC64;
MSKEKQCRPG PRVPKCSRCR NHSLKTPLKG HKRFCRWKDC HCLKCKLIVD RQRVMAAQVA
LRRQQAQEEE LGICSPEASS GPEVVVKNEA GADCLFSVEG RSGTPAPPPN PNPLSVAGSY
SASSSSPSAA ARVYSEEASD QPLETSYYNF YQPSRYSSYY GNLYNYQQYQ QMPPSDGRLS
GHSMPSQYRM HSFYPGTAYL PQGLGSPVPP YFSLEDNDGA AASFFPSSLT STHDSTLTYR
SISSLVNDGV KAEFESGGQP PSSRPTP
