ID   DMTA2_BOVIN             Reviewed;         535 AA.
AC   A6QQ94;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=DMRTA2; Synonyms=DMRT5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; BC149711; AAI49712.1; -; mRNA.
DR   RefSeq; NP_001096751.1; NM_001103281.2.
DR   AlphaFoldDB; A6QQ94; -.
DR   SMR; A6QQ94; -.
DR   STRING; 9913.ENSBTAP00000013742; -.
DR   PaxDb; A6QQ94; -.
DR   GeneID; 537680; -.
DR   KEGG; bta:537680; -.
DR   CTD; 63950; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   HOGENOM; CLU_038477_2_0_1; -.
DR   InParanoid; A6QQ94; -.
DR   OrthoDB; 1573364at2759; -.
DR   TreeFam; TF317837; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..535
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333771"
FT   DOMAIN          313..348
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        69..116
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          200..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  52989 MW;  EDF0E48BA831AACD CRC64;
     MELRSELPSV PGAATAAATA TGPPVASVAS VAAAAAAAAS LPVSVAGGLL RAPPLLLRAA
     EKYPRTPKCA RCRNHGVVSA LKGHKRYCRW KDCLCAKCTL IAERQRVMAA QVALRRQQAQ
     EENEARELQL LYGTAEGLAL AAANGIIPPR PAYEVFGSVC AADGGGPGAG APAGTGGGAA
     GAGSSEAKLQ KFDLFPKTLL QAGRPGSPQP QPGKPLSPDG ADSGPGTSSP EVRPGSGSEN
     GDGESFSGSP LARASKEAGG SCPGSAGPGG GGEEDSPGSA SPLGSESGSE ADKEEAEASP
     APGLGGGPGP RQRTPLDILT RVFPGHRRGV LELVLQGCGG DVVQAIEQVL NHHRGGLAAG
     LGPTVPPDKA AVGAVGAADD AWPGRVDAAA AGGPGLPAPL QAGPAAPPHH RPLLAGAMAP
     GALGSLSSRS AFSPLQPNAS HFGADAGAYP LGAPLGLSPL RLAYSAAAAH SRGLAFMAPY
     STAGLVPTLG FRPPMDYAFS DLMRDRSAAA AAVHKEPTYG GGLYGPMVNG APEKQ