ID   DMTA2_DANRE             Reviewed;         440 AA.
AC   Q5UU75;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=dmrta2; Synonyms=dmrt5;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15474464; DOI=10.1016/j.bbrc.2004.09.085;
RA   Guo Y., Li Q., Gao S., Zhou X., He Y., Shang X., Cheng H., Zhou R.;
RT   "Molecular cloning, characterization, and expression in brain and gonad of
RT   Dmrt5 of zebrafish.";
RL   Biochem. Biophys. Res. Commun. 324:569-575(2004).
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Restrictively expressed in brain and developing
CC       germ cells, especially in spermatogonia, spermatocytes, spermatids, and
CC       sperm cells, and in developing oocytes, including early perinucleolus
CC       stage oocyte, late yolk vesicle stage oocyte, and oil drop stage
CC       oocyte. {ECO:0000269|PubMed:15474464}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in early gastrula period, subsequently
CC       increases to a high level in late stage of gastrula period (bud stage)
CC       and lowers until the hatch period. Expressed in developing central
CC       nervous system of embryos, especially in mid-brain and mid-hind brain
CC       boundary. Seems to be restricted in central nervous system, especially
CC       in mid-brain and mid-hind brain boundary.
CC       {ECO:0000269|PubMed:15474464}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AY618549; AAU85258.1; -; mRNA.
DR   AlphaFoldDB; Q5UU75; -.
DR   SMR; Q5UU75; -.
DR   STRING; 7955.ENSDARP00000057589; -.
DR   PaxDb; Q5UU75; -.
DR   ZFIN; ZDB-GENE-041116-2; dmrta2.
DR   eggNOG; KOG3815; Eukaryota.
DR   InParanoid; Q5UU75; -.
DR   PhylomeDB; Q5UU75; -.
DR   PRO; PR:Q5UU75; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060128; P:corticotropin hormone secreting cell differentiation; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   GO; GO:0021537; P:telencephalon development; IMP:ZFIN.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..440
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333774"
FT   DOMAIN          261..296
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        59..106
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          167..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  47333 MW;  6760A64F985E1F91 CRC64;
     MDLRPEIPPA SQAGSQVHPG AAAAAAAAAS IPVSMAGSLL RAPPLLLRAT EKYPRTPKCA
     RCRNHGVVSA LKGHKRYCRW KDCMCAKCTL IAERQRVMAA QVALRRQQAQ EENEARELQL
     LYGTAEGLAL AAANGIIPPR QNYEVFGPVS NESNSGESNI QKFELFPKTP LPGTVTPHQA
     AGKSVSTDTE SVPGMSSPDM RHGSGSENGD RESIVSSPIA KPLKDGEETP GSISPIGSDS
     GSDTDKDEQE PSPSSAASRQ MNAIDILTRV FPNHKRSVLE LVLQGCGKNV VQAIEQILNN
     SGQAKGPEET WTAERMLQSV QPTMSSTPRP MLPGTMTLSN RSAFSPLQPN APHFGSDPST
     YPLSTHLGLN PLRLAYSAHS RGLAFMAPYS TTGLMPTLGF RPPMDYAFSD LIRDRTLLHK
     DQSYTNGLYG PLVNNTQEKQ