ID   DMTA2_MOUSE             Reviewed;         531 AA.
AC   A2A9A2; Q8CFF8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=Dmrta2; Synonyms=Dmrt5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=12609607; DOI=10.1016/s1567-133x(02)00071-6;
RA   Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
RT   "Sexually dimorphic expression of multiple doublesex-related genes in the
RT   embryonic mouse gonad.";
RL   Gene Expr. Patterns 3:77-82(2003).
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Expressed in adult brain and testis, as well as in
CC       embryonic ovary, kidney, heart, lung, stomach and brain.
CC       {ECO:0000269|PubMed:12609607}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from 12.5 dpc to 15.5 dpc in ovary and
CC       from 12.5 dpc to 14.5 dpc in testis, but to a lower extent. Expression
CC       is detectable in early embryos at 8.5 dpc and in brain of embryos at
CC       13.5 dpc. {ECO:0000269|PubMed:12609607}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AY145837; AAN10254.1; -; mRNA.
DR   EMBL; AL627188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS18469.1; -.
DR   RefSeq; NP_758500.2; NM_172296.2.
DR   RefSeq; XP_006503156.1; XM_006503093.3.
DR   RefSeq; XP_006503157.1; XM_006503094.3.
DR   AlphaFoldDB; A2A9A2; -.
DR   SMR; A2A9A2; -.
DR   STRING; 10090.ENSMUSP00000060441; -.
DR   iPTMnet; A2A9A2; -.
DR   PhosphoSitePlus; A2A9A2; -.
DR   PaxDb; A2A9A2; -.
DR   PRIDE; A2A9A2; -.
DR   ProteomicsDB; 279735; -.
DR   Antibodypedia; 32925; 103 antibodies from 21 providers.
DR   DNASU; 242620; -.
DR   Ensembl; ENSMUST00000061187; ENSMUSP00000060441; ENSMUSG00000047143.
DR   GeneID; 242620; -.
DR   KEGG; mmu:242620; -.
DR   UCSC; uc008ucv.1; mouse.
DR   CTD; 63950; -.
DR   MGI; MGI:2653629; Dmrta2.
DR   VEuPathDB; HostDB:ENSMUSG00000047143; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00940000161649; -.
DR   HOGENOM; CLU_038477_1_0_1; -.
DR   InParanoid; A2A9A2; -.
DR   OMA; AYPLGTH; -.
DR   OrthoDB; 1573364at2759; -.
DR   PhylomeDB; A2A9A2; -.
DR   TreeFam; TF317837; -.
DR   BioGRID-ORCS; 242620; 1 hit in 74 CRISPR screens.
DR   PRO; PR:A2A9A2; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2A9A2; protein.
DR   Bgee; ENSMUSG00000047143; Expressed in floor plate of midbrain and 75 other tissues.
DR   Genevisible; A2A9A2; MM.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0021796; P:cerebral cortex regionalization; IMP:MGI.
DR   GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:MGI.
DR   GO; GO:0007405; P:neuroblast proliferation; IMP:MGI.
DR   GO; GO:0048665; P:neuron fate specification; IMP:MGI.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR   GO; GO:0048863; P:stem cell differentiation; IMP:MGI.
DR   GO; GO:0048866; P:stem cell fate specification; IMP:MGI.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..531
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333773"
FT   DOMAIN          310..345
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        69..116
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          197..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        389
FT                   /note="A -> V (in Ref. 1; AAN10254)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   531 AA;  52927 MW;  AEFA03DBFE1D8927 CRC64;
     MELRSELPSV PGAATAAATA TGPPVASVAS VAAAAAAAAS LPVSVAGGLL RAPPLLLRAA
     EKYPRTPKCA RCRNHGVVSA LKGHKRYCRW KDCLCAKCTL IAERQRVMAA QVALRRQQAQ
     EENEARELQL LYGTAEGLAL AAANGIIPPR PAYEVFGSVC ATDGGGPGAG APAGSAGGAG
     GAEAKLQKFD LFPKTLLQAG RPDSPQPPPG KPLSPDGADS GPRTSSPEVR PGSGSENGDG
     ESFSGSPLAR ASKEAGGSCP GSAGAGGGGE EDSPGSSSPL GSESGSEADK EEAEAAPTPG
     LGGGPGPRQR TPLDILTRVF PGHRRGVLEL VLQGCGGDVV QAIEQVLNHH RGGLAAGLGP
     AAPLEKAAVS AAVEDAWPGR VEAAAAGGAG LPAPLQTGPT APPHHRPLLA GAMTPGALGS
     LSSRSAFSPL QPNASHFGAD AGAYPLGAPL GLSPLRLAYS AAAAHSRGLA FMAPYSTAGL
     VPTLGFRPPM DYAFSDLMRD RSAAAAAAVH KEPGYGGGLY GPMVNGTPEK Q