ID   DMTA2_ORENI             Reviewed;         449 AA.
AC   Q6YHU8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=dmrta2; Synonyms=dmrt5;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Testis;
RA   Guan G., Kobayashi T., Nagahama Y.;
RT   "Novel DM domain genes of Tilapia.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AY149605; AAN78445.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6YHU8; -.
DR   SMR; Q6YHU8; -.
DR   STRING; 8128.ENSONIP00000002957; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   InParanoid; Q6YHU8; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..449
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333777"
FT   DOMAIN          260..295
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        57..104
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          166..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  47547 MW;  C0945510082EAF96 CRC64;
     MDLRPELPTA SSASQVHPGA AAAAAAASIP VSMAGNLLRG PPLLLRAADK YPRTPKCARC
     RNHGVVSALK GHKRYCRWKD CMCAKCTLIA ERQRVMAAQV ALRRQQAQEE SEARELQLLY
     GTAEGPAIAA ANGIIPPRPN YEVFGSVSSE SNSADSSIQK YELFPKNQLS GSATPQPSAG
     KPASTEGDSA PGISSPDGRH GGSGSENGDS ESFISSPVSK PLKDGEETPG SVSSIGSDSG
     SETDKDDQEP SPSSAASRHM NAIDILTRVF PSHKRSVLEL VLQGCGKDVV QAIEQILNNS
     GAQGPNKAGP DETWTAERML QNAQQLPAAS ATTTAPTRPM LPGAMTLSNR SAFSPLQPNA
     PHFGADPSTY PLGTHLGLNP LRLAYSAHSR GLAFMTPYST TGLMPTLGFR PPMYYAFSDL
     IRDRTMLHKE QGYASGLYGP LVNNTPEKQ