DMTA2_ORYLA
ID DMTA2_ORYLA Reviewed; 416 AA.
AC Q76L87;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE AltName: Full=Doublesex- and mab-3-related transcription factor 5;
DE Short=Ola-DMRT5;
GN Name=dmrta2; Synonyms=dmrt5;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HNI; TISSUE=Testis;
RA Kitano A., Kondo M., Shima A.;
RT "Molecular cloning and expression analysis of DMRT5 genes of the medaka
RT Oryzias latipes.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in sexual development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR EMBL; AB083691; BAD00703.1; -; Genomic_DNA.
DR AlphaFoldDB; Q76L87; -.
DR SMR; Q76L87; -.
DR InParanoid; Q76L87; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR Gene3D; 4.10.1040.10; -; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR SUPFAM; SSF82927; SSF82927; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT CHAIN 1..416
FT /note="Doublesex- and mab-3-related transcription factor
FT A2"
FT /id="PRO_0000333778"
FT DOMAIN 228..263
FT /note="DMA"
FT /evidence="ECO:0000255"
FT DNA_BIND 25..72
FT /note="DM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT REGION 133..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 44480 MW; CCE265588BB54399 CRC64;
MAGNLLRGPP LLLRAADKYP RTPKCARCRN HGVVSALKGH KRYCRWKDCM CAKCTLIAER
QRVMAAQVAL RRQQAQEENE ARELQLLYGT AEGLALAAAN GIIPPRPNYE VFGSVSSESN
SESSIPKYEL FPKSQLSSST PPQQSGGKPV SAESDSAPGI SSPDARHEGG SGSENGDSES
FINSPVSKPL KDGEETPGSV SSLGSDSGSE IDKDEQEPSP SSVASRHMNA IDILTRVFPS
HKRSVLELVL QGCGKDVVQA IEQILNNGGA QAPKAGAEET WTAERMLQSA QQLPAASATT
APSSRPMLPG AMALSNRSAF SPLQPNAPHF GADPGSYPLG THLGLNPLRL AYSAHSRGLA
FMTPYSTTGL MPTLGFRPPM DYAFSDLIRD RTMLHKEQPY ASGLYGPLVN NTPDKQ