ID   DMTA2_TAKRU             Reviewed;         416 AA.
AC   Q4AE28;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=dmrta2; Synonyms=dmrt5;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Larva;
RA   Yamaguchi A.;
RT   "Expression of the DMRT gene and its roles in early gonadal development of
RT   the Japanese pufferfish Takifugu rubripes.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AB201465; BAE16956.1; -; mRNA.
DR   RefSeq; NP_001033039.1; NM_001037950.1.
DR   AlphaFoldDB; Q4AE28; -.
DR   SMR; Q4AE28; -.
DR   STRING; 31033.ENSTRUP00000004208; -.
DR   GeneID; 654282; -.
DR   KEGG; tru:654282; -.
DR   CTD; 63950; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   InParanoid; Q4AE28; -.
DR   OrthoDB; 1573364at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..416
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333775"
FT   DOMAIN          227..262
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        25..72
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          131..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  44288 MW;  C645781DF9FF21C4 CRC64;
     MAGNLLRGPP LLLRASDKYP RTPKCARCRN HGVVSALKGH KRYCRWKDCM CAKCTLIAER
     QRVMAAQVAL RRQQAQEENE VRELQLLYGT AEGLALAAAN GIIPPRPNYE VFGSVSSESN
     SDSSVQKFET FSKGQLSGPT TPQQAAGKSA SAESDSAPGM SSPDGRHGGS GSENGDSESF
     INSPVSKPLK DGGETPGSVS SIGSDSGSET DKDEQEPSPS SAASRHMNAI DILTRVFPSH
     KRSILELVLQ GCGKDVVQAI EQILNNSGAQ GSNKAGPDEG WTAERMLQGA QQPPPPPAAS
     TAPTRPLLPG AMTLSNRSAF SPLQPNTPHF GADPSTYPLG THLGLNPLRL AYSAHGRGLA
     FMTPYSTTGL MPTLGFRPPM DYAFSDLIRD RTMLHKEQGY SGGLYGPLVN NTTEKQ