ID   DMTA2_XENTR             Reviewed;         437 AA.
AC   A4QNP7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=dmrta2; Synonyms=dmrt5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; BC136032; AAI36033.1; -; mRNA.
DR   RefSeq; NP_001096543.1; NM_001103073.1.
DR   RefSeq; XP_017948385.1; XM_018092896.1.
DR   AlphaFoldDB; A4QNP7; -.
DR   SMR; A4QNP7; -.
DR   STRING; 8364.ENSXETP00000006216; -.
DR   PaxDb; A4QNP7; -.
DR   DNASU; 100125187; -.
DR   Ensembl; ENSXETT00000006216; ENSXETP00000006216; ENSXETG00000002846.
DR   GeneID; 100125187; -.
DR   KEGG; xtr:100125187; -.
DR   CTD; 63950; -.
DR   Xenbase; XB-GENE-997963; dmrta2.
DR   eggNOG; KOG3815; Eukaryota.
DR   InParanoid; A4QNP7; -.
DR   OrthoDB; 1573364at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002846; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..437
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333781"
FT   DOMAIN          254..289
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        49..96
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          163..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   437 AA;  46420 MW;  91726B89C851BF6C CRC64;
     MELNGPPVSQ LPQTATSTAS LPVTVAGTLL RGPQLLLRAA EKYPRTPKCA RCRNHGVVSA
     LKGHKRYCRW KDCMCAKCTL IAERQRVMAA QVALRRQQAQ EENEARELQL LYGTAEGLAL
     AAANGIIPPR PAYEVFGSVC TEGGTDSKIQ KFDLFPKSLI PRSVTPQLSS GGKPVSPDSE
     SVSGSAPGAS SPEARPGSGS ENGDGESLLS SPISKALKEG EESPSSISPL GSESGSDAEK
     DEQDPSSSSS ARQRTPIDIL TRVFPAQKRS VLELVLQGCG GDVVQAIEQI LNNRGQDKSE
     ETWSRDGALP SIQPSVSSTH RPLIAGALTP AIGTLGSRSA FSPLQPNGAH FGTEANAYQL
     GGHLGLNPLR LAYSAHSRGL AFMAPYSTAG FMPTLGFRPP MDYAFSDLMR DRANVHKDQV
     YTNGLYGPVV NNNAEKQ