ID   DMTA2_XIPMA             Reviewed;         449 AA.
AC   Q2I327;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor A2;
DE   AltName: Full=Doublesex- and mab-3-related transcription factor 5;
GN   Name=dmrta2; Synonyms=dmrt5;
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=18377213; DOI=10.1089/zeb.2006.3.325;
RA   Veith A.-M., Schafer M., Kluver N., Schmidt C., Schultheis C., Schartl M.,
RA   Winkler C., Volff J.-N.;
RT   "Tissue-specific expression of dmrt genes in embryos and adults of the
RT   Platyfish Xiphophorus maculatus.";
RL   Zebrafish 3:325-337(2006).
CC   -!- FUNCTION: May be involved in sexual development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain and eye.
CC       {ECO:0000269|PubMed:18377213}.
CC   -!- DEVELOPMENTAL STAGE: From E3, expressed in the olfactory placode,
CC       forebrain, midbrain, and lenses. At later stages, expression in the
CC       lenses is no longer detectable but is found in the fore- and ventral
CC       mid-brain and in the mid-hind-brain boundary. At E5, expressed in
CC       olfactory epithelium and brain. {ECO:0000269|PubMed:18377213}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; DQ335470; ABC60024.1; -; Genomic_DNA.
DR   RefSeq; XP_005806419.1; XM_005806362.1.
DR   AlphaFoldDB; Q2I327; -.
DR   SMR; Q2I327; -.
DR   STRING; 8083.ENSXMAP00000003337; -.
DR   Ensembl; ENSXMAT00000003342; ENSXMAP00000003337; ENSXMAG00000003327.
DR   GeneID; 102221849; -.
DR   KEGG; xma:102221849; -.
DR   CTD; 63950; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00940000161649; -.
DR   HOGENOM; CLU_038477_1_0_1; -.
DR   InParanoid; Q2I327; -.
DR   OMA; AYPLGTH; -.
DR   OrthoDB; 1573364at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc.
FT   CHAIN           1..449
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   A2"
FT                   /id="PRO_0000333779"
FT   DOMAIN          260..295
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        57..104
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          163..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  47682 MW;  4F5288DB190ADD0B CRC64;
     MDLRPELPTV SSASQVHPGA AAAAAAASIP VSMAGNLLRG PPLLLRAADK YPRTPKCARC
     RNHGVVSALK GHKRYCRWKD CMCAKCTLIA ERQRVMAAQV ALRRQQAQEE NEARELQLLY
     GTAEGLALAA ANGIIPPRPN YEVFGSVNSE SNSESSIQKY ELFPKTQLSG STTTQKSVGK
     PASTESDSAP GMSSPDGRHG GGSGSENGDS ESFINSPVSK PLKDGEETPG SVSSLGSDSG
     SETDKEEQEP SPSSAASRHM NAIDILTRVF PSHKRSVLEL VLQGCGKDVV QAIEQILNNS
     GAQAPNKAGP EETWTAERML QSAQQPPAGS ATAATTTRPM LPGAMTLSNR SAFSPLQPNA
     PHFGADPGTY PLGTHLGLNP LRLAYSAHSR GLAFMTPYST TGLMPTLGFR PPMDYAFSDL
     IRDRTMLHKE QGYASGLYGP LVNNTPDKQ