DMTF1_DANRE
ID DMTF1_DANRE Reviewed; 645 AA.
AC Q6DG03; Q5RGE9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cyclin-D-binding Myb-like transcription factor 1;
GN Name=dmtf1; ORFNames=si:dkey-153k10.8, zgc:92448;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator which activates the CDKN2A/ARF
CC locus in response to Ras-Raf signaling, thereby promoting p53/TP53-
CC dependent growth arrest. Binds to the consensus sequence 5'-
CC CCCG[GT]ATGT-3'. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DG03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DG03-2; Sequence=VSP_034966, VSP_034967, VSP_034968;
CC -!- SIMILARITY: Belongs to the DMTF1 family. {ECO:0000305}.
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DR EMBL; BX901962; CAI20680.2; -; Genomic_DNA.
DR EMBL; BC076552; AAH76552.1; -; mRNA.
DR RefSeq; NP_001002665.1; NM_001002665.1. [Q6DG03-1]
DR AlphaFoldDB; Q6DG03; -.
DR SMR; Q6DG03; -.
DR STRING; 7955.ENSDARP00000028305; -.
DR PaxDb; Q6DG03; -.
DR Ensembl; ENSDART00000029084; ENSDARP00000028305; ENSDARG00000025824. [Q6DG03-1]
DR Ensembl; ENSDART00000180105; ENSDARP00000152372; ENSDARG00000025824. [Q6DG03-2]
DR Ensembl; ENSDART00000187373; ENSDARP00000148434; ENSDARG00000109819. [Q6DG03-1]
DR Ensembl; ENSDART00000189671; ENSDARP00000145142; ENSDARG00000025824. [Q6DG03-1]
DR GeneID; 436938; -.
DR KEGG; dre:436938; -.
DR CTD; 9988; -.
DR ZFIN; ZDB-GENE-040718-413; dmtf1.
DR eggNOG; KOG0051; Eukaryota.
DR GeneTree; ENSGT00940000156016; -.
DR InParanoid; Q6DG03; -.
DR OMA; WEDLAWG; -.
DR PhylomeDB; Q6DG03; -.
DR TreeFam; TF333537; -.
DR PRO; PR:Q6DG03; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000025824; Expressed in blastula and 20 other tissues.
DR ExpressionAtlas; Q6DG03; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 4.
DR SUPFAM; SSF46689; SSF46689; 3.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Cell cycle; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Tumor suppressor.
FT CHAIN 1..645
FT /note="Cyclin-D-binding Myb-like transcription factor 1"
FT /id="PRO_0000323732"
FT DOMAIN 219..257
FT /note="Myb-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 262..327
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 333..382
FT /note="Myb-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DNA_BIND 300..323
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 34..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 395
FT /note="V -> A (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034966"
FT VAR_SEQ 396..446
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034967"
FT VAR_SEQ 528..531
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034968"
SQ SEQUENCE 645 AA; 71268 MW; AB5832B045A7861B CRC64;
MNTGDVPATV TLESVNSVTF TQDTDGNIIL HCPQNDGEDL GSDETTEPVH KRIRLSSEDG
EDPQDSASTE YSVVTLPITD GDESFEVTMT ATEMRDEELE SDDLSETTGK DSSAQKKGED
VSAVSQAWFT TKEDKDTLVN KGHKWKQGMW SKEEIDLLMT NIELYLKNRG IQDPAEIIFE
MSKEERKDFY RSIACGLNRP LFAVYRRVLR MYDNRNHVGK YTDEEINKLK ELRQKHGNDW
ATIGSALGRS ASSVKDRCRL MKDTCNTGKW TEEEERRLAE VVHELTGTEA GDVVTQGVSW
ASVAELVGTR SEKQCRSKWL NYLNWKQSGG TEWTKEDDIN LVRRIAELEV EDENEINWDI
LASGWSSVRS PQWLRSKWWT IKRQVANHKE LPFPVLLKGL QDVVEAPPST MNKVVVVGSR
SANASPSPVT ALQIPVQIPV QITHVSSSDG SSGTSDSETI TLNSGALQTF ELLPSFHLQP
TGTPGTYFLQ TGTNQSLPLT LSANPTVTLT AAASPSSPDQ IILHSLTTDT ENVTVQMSHP
GIIIQTVTSE DLADPLGQSE LEGEQVLVKE EPSENQTNPA IEEPSEEQSK QGEKTLDSSK
VVETVLMVPS PGSFIPTNED ISSDSVLPLG TLTDPILENQ EEGSN
