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DMTF1_RAT
ID   DMTF1_RAT               Reviewed;         760 AA.
AC   Q66HG1; Q99MC8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Cyclin-D-binding Myb-like transcription factor 1;
GN   Name=Dmtf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 449-527 (ISOFORM 2).
RC   STRAIN=Brown Norway;
RX   PubMed=11707776; DOI=10.1007/s00335-001-2090-2;
RA   Walentinsson A., Helou K., Levan G.;
RT   "A dual-color FISH gene map of the proximal region of rat chromosome 4 and
RT   comparative analysis in human and mouse.";
RL   Mamm. Genome 12:900-908(2001).
CC   -!- FUNCTION: Transcriptional activator which activates the CDKN2A/ARF
CC       locus in response to Ras-Raf signaling, thereby promoting p53/TP53-
CC       dependent growth arrest. Binds to the consensus sequence 5'-
CC       CCCG[GT]ATGT-3'. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the D-type cyclins CCND1, CCND2 and CCND3.
CC       Interaction with D-type cyclins may modulate transcriptional activation
CC       by this protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q66HG1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q66HG1-2; Sequence=VSP_032102;
CC   -!- PTM: Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-
CC       D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DMTF1 family. {ECO:0000305}.
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DR   EMBL; AABR03031952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC081880; AAH81880.1; -; mRNA.
DR   EMBL; AF352170; AAK32706.1; -; mRNA.
DR   RefSeq; NP_446145.1; NM_053693.1. [Q66HG1-2]
DR   RefSeq; XP_017447870.1; XM_017592381.1. [Q66HG1-1]
DR   AlphaFoldDB; Q66HG1; -.
DR   SMR; Q66HG1; -.
DR   STRING; 10116.ENSRNOP00000046030; -.
DR   PaxDb; Q66HG1; -.
DR   Ensembl; ENSRNOT00000044810; ENSRNOP00000046030; ENSRNOG00000005908. [Q66HG1-1]
DR   GeneID; 114485; -.
DR   KEGG; rno:114485; -.
DR   CTD; 9988; -.
DR   RGD; 70966; Dmtf1.
DR   eggNOG; KOG0051; Eukaryota.
DR   GeneTree; ENSGT00940000156016; -.
DR   HOGENOM; CLU_021360_1_0_1; -.
DR   InParanoid; Q66HG1; -.
DR   OMA; WEDLAWG; -.
DR   OrthoDB; 1474117at2759; -.
DR   PhylomeDB; Q66HG1; -.
DR   TreeFam; TF333537; -.
DR   PRO; PR:Q66HG1; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000005908; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q66HG1; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00167; SANT; 3.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 2.
DR   SMART; SM00717; SANT; 3.
DR   SUPFAM; SSF46689; SSF46689; 3.
DR   PROSITE; PS51294; HTH_MYB; 1.
DR   PROSITE; PS50090; MYB_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; Cell cycle; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Tumor suppressor.
FT   CHAIN           1..760
FT                   /note="Cyclin-D-binding Myb-like transcription factor 1"
FT                   /id="PRO_0000323731"
FT   DOMAIN          225..263
FT                   /note="Myb-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DOMAIN          268..333
FT                   /note="HTH myb-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          339..388
FT                   /note="Myb-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT   DNA_BIND        306..329
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          1..237
FT                   /note="Interaction with CCND2"
FT                   /evidence="ECO:0000250"
FT   REGION          24..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..458
FT                   /note="Required for DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          87..170
FT                   /note="Required for transcriptional activation"
FT                   /evidence="ECO:0000250"
FT   REGION          176..690
FT                   /note="Interaction with CCND1, CCND2 and CCND3"
FT                   /evidence="ECO:0000250"
FT   REGION          459..760
FT                   /note="Required for transcriptional activation"
FT                   /evidence="ECO:0000250"
FT   REGION          593..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         401..471
FT                   /note="VLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDNTA
FT                   ISPSPMAALQIPVQITHVS -> A (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11707776,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032102"
SQ   SEQUENCE   760 AA;  84452 MW;  83F3FB5675DBC30B CRC64;
     MSTVEEDSDT VTVETVNSVT FTQDTDGNLI LHCPQNDPDE IDSEDSTEPP HKRLCLSSED
     DQSIDDSTPC ISVVALPLSE NDQSFEVTMT ATTEVADDEL SEGTVTQIQI LQNDQLDEMS
     PLGTEEVSAV SQAWFTTKED KDSLTNKGHK WKQGMWSKEE IDILMNNIER YLKARGIKDA
     TEIIFEMSKD ERKDFYRTIA WGLNRPLFAV YRRVLRMYDD RNHVGKYTPE EIEKLKELRI
     KHGNDWATIG AALGRSASSV KDRCRLMKDT CNTGKWTEEE EKRLAEVVHE LTSTEPGDIV
     TQGVSWAAVA ERVGTRSEKQ CRSKWLNYLN WKQSGGTEWT KEDEINLILR IAELDVADEN
     DINWDLLAEG WSSVRSPQWL RSKWWTIKRQ IANHKDVSFP VLIKGLKQLH ENQKNNPVLL
     ENKSGSGVPN SNCNSSVQHV QIRVARLEDN TAISPSPMAA LQIPVQITHV SSTDSPAASV
     DSETITLNSG TLQTFEILPS FHLQPTGTPG TYLLQTSSSQ GLPLTLTTSP TVTLAAAAPA
     SPEQIIVHAL SPEHLLNTSD NVTVQCHTPR VIIQTVATED ITSSISQAEL TADSDLHSSD
     FPEPPDALEA DTFPDEIPRP KMTIQPSFNN AHVSKYSDQN STELMNSVMV RTEEEIADTD
     LKQEPPSDLA SAYVTEDLES PTIVHQVHQT IDDETILIVP SPHGFIQASD GIDAESVLPL
     TTLTDPIFQH HQEESNIIGS SLGSPVSEDS KDVEDLVNCH
 
 
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