ID   DMW_XENLA               Reviewed;         194 AA.
AC   B0I1G7;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor DM-W;
DE   AltName: Full=W-linked doublesex- and mab-3-related transcription factor;
DE            Short=xDM-W;
GN   Name=dm-w;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Gonad;
RX   PubMed=18268317; DOI=10.1073/pnas.0712244105;
RA   Yoshimoto S., Okada E., Umemoto H., Tamura K., Uno Y., Nishida-Umehara C.,
RA   Matsuda Y., Takamatsu N., Shiba T., Ito M.;
RT   "A W-linked DM-domain gene, DM-W, participates in primary ovary development
RT   in Xenopus laevis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2469-2474(2008).
RN   [2]
RP   FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
RX   PubMed=20573695; DOI=10.1242/dev.048751;
RA   Yoshimoto S., Ikeda N., Izutsu Y., Shiba T., Takamatsu N., Ito M.;
RT   "Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual
RT   dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-determining
RT   system.";
RL   Development 137:2519-2526(2010).
CC   -!- FUNCTION: Transcription factor that plays a key role in female sex
CC       determination and primary ovary development. Acts as a sex-determining
CC       protein by antagonizing the transcriptional activity of male-
CC       determination protein dmrt1-a, acting as a dominant-negative type
CC       protein. {ECO:0000269|PubMed:18268317, ECO:0000269|PubMed:20573695}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in the primordial gonads of
CC       ZW tadpoles. Specifically expressed in the somatic cells surrounding
CC       primordial germ cells in a ZW gonad at stage 50 during sex
CC       determination (at protein level). {ECO:0000269|PubMed:18268317,
CC       ECO:0000269|PubMed:20573695}.
CC   -!- DEVELOPMENTAL STAGE: Barely detectable at stage 52 in the ZW gonads.
CC       {ECO:0000269|PubMed:18268317}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; AB259777; BAG06159.1; -; mRNA.
DR   RefSeq; NP_001108314.1; NM_001114842.1.
DR   AlphaFoldDB; B0I1G7; -.
DR   SMR; B0I1G7; -.
DR   GeneID; 100137717; -.
DR   KEGG; xla:100137717; -.
DR   CTD; 100137717; -.
DR   OrthoDB; 1209937at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 100137717; Expressed in ovary.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008585; P:female gonad development; IMP:UniProtKB.
DR   GO; GO:0030237; P:female sex determination; IMP:UniProtKB.
DR   GO; GO:0046660; P:female sex differentiation; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR022114; DMRT1-like.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF12374; Dmrt1; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Sexual differentiation; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..194
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   DM-W"
FT                   /id="PRO_0000416902"
FT   DNA_BIND        28..75
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  21489 MW;  9670979EA2FD889C CRC64;
     MQNNEEPYNT GQYPSGPHGK KSPRLHKCAR CRNHGYATPL KGHKRFCIWR DCQCQKCSLI
     TERQRVIAAQ VALQRQQAQE EELGIYHPIP LPIAAVIKRE HGGSSSQLML ESSSTQTTST
     PTSAEWIKEE EVAKPAAGLF APPPSSEEMG MTLAAVGAAD AATQTDQPGH LFNMMSAMIQ
     QLMDMSWELQ QGWI