DMX1A_DANRE
ID DMX1A_DANRE Reviewed; 388 AA.
AC Q8JI10; Q8JI09;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Diencephalon/mesencephalon homeobox protein 1-A;
DE AltName: Full=Paired homeobox protein 1;
GN Name=dmbx1a {ECO:0000312|ZFIN:ZDB-GENE-020117-1};
GN Synonyms=dmbx1 {ECO:0000312|ZFIN:ZDB-GENE-020117-1},
GN mbx {ECO:0000303|PubMed:12142024}, mbx1 {ECO:0000303|PubMed:16733737},
GN pox1 {ECO:0000312|EMBL:AAL58532.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAM90587.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12142024; DOI=10.1006/dbio.2002.0709;
RA Kawahara A., Chien C.-B., Dawid I.B.;
RT "The homeobox gene mbx is involved in eye and tectum development.";
RL Dev. Biol. 248:107-117(2002).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=16733737; DOI=10.1007/s00427-006-0082-7;
RA Chang L., Khoo B., Wong L., Tropepe V.;
RT "Genomic sequence and spatiotemporal expression comparison of zebrafish
RT mbx1 and its paralog, mbx2.";
RL Dev. Genes Evol. 216:647-654(2006).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL58532.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Bayarsaihan D.;
RT "A novel zebrafish paired-like homeobox gene.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for eye and tectum development. May act as a
CC transcriptional repressor. {ECO:0000269|PubMed:12142024}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35137,
CC ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-
CC ProRule:PRU00138}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:12142024, ECO:0000269|Ref.3}; Synonyms=Mbx-L
CC {ECO:0000312|EMBL:AAM90587.1};
CC IsoId=Q8JI10-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12142024}; Synonyms=Mbx-S
CC {ECO:0000312|EMBL:AAM90588.1};
CC IsoId=Q8JI10-2; Sequence=VSP_052250;
CC -!- TISSUE SPECIFICITY: In embryos, expressed in mesencephalon with
CC strongest expression dorsally, diencephalon, and rhombencephalon.
CC During somitogenesis, anterior expression which partly overlaps the
CC future eye field, gradually decreases while midbrain expression
CC intensifies and becomes restricted to the presumptive tectum. In adult,
CC strong expression in forebrain, midbrain and cerebellum.
CC {ECO:0000269|PubMed:12142024, ECO:0000269|PubMed:16733737}.
CC -!- DEVELOPMENTAL STAGE: Not expressed maternally. First detected at 9
CC hours post-fertilization (hpf), with high levels until 24 hpf. Also
CC expressed in adult. {ECO:0000269|PubMed:12142024,
CC ECO:0000269|PubMed:16733737}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AF398525; AAM90587.1; -; mRNA.
DR EMBL; AF398526; AAM90588.1; -; mRNA.
DR EMBL; AY071922; AAL58532.1; -; mRNA.
DR RefSeq; NP_694509.1; NM_152977.1. [Q8JI10-1]
DR RefSeq; NP_835457.2; NM_178163.2. [Q8JI10-2]
DR RefSeq; XP_017213101.1; XM_017357612.1.
DR AlphaFoldDB; Q8JI10; -.
DR SMR; Q8JI10; -.
DR STRING; 7955.ENSDARP00000027577; -.
DR PaxDb; Q8JI10; -.
DR Ensembl; ENSDART00000017173; ENSDARP00000027577; ENSDARG00000009922. [Q8JI10-1]
DR Ensembl; ENSDART00000128535; ENSDARP00000106835; ENSDARG00000009922. [Q8JI10-2]
DR Ensembl; ENSDART00000189122; ENSDARP00000148506; ENSDARG00000009922. [Q8JI10-2]
DR GeneID; 142987; -.
DR KEGG; dre:142987; -.
DR CTD; 142987; -.
DR ZFIN; ZDB-GENE-020117-1; dmbx1a.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000155505; -.
DR HOGENOM; CLU_060969_0_0_1; -.
DR InParanoid; Q8JI10; -.
DR OMA; HREEPKG; -.
DR OrthoDB; 1270742at2759; -.
DR PhylomeDB; Q8JI10; -.
DR TreeFam; TF351609; -.
DR PRO; PR:Q8JI10; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000009922; Expressed in retina and 31 other tissues.
DR ExpressionAtlas; Q8JI10; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEP:UniProtKB.
DR GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
DR GO; GO:0001654; P:eye development; IEP:UniProtKB.
DR GO; GO:0030901; P:midbrain development; IMP:ZFIN.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IGI:ZFIN.
DR GO; GO:0061074; P:regulation of neural retina development; IGI:ZFIN.
DR GO; GO:0050767; P:regulation of neurogenesis; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Developmental protein; DNA-binding;
KW Homeobox; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..388
FT /note="Diencephalon/mesencephalon homeobox protein 1-A"
FT /id="PRO_0000262956"
FT DNA_BIND 71..130
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 129..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 206..232
FT /evidence="ECO:0000255"
FT MOTIF 365..378
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 159..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 52..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12142024,
FT ECO:0000303|PubMed:16733737"
FT /id="VSP_052250"
SQ SEQUENCE 388 AA; 42716 MW; 255940C596903C22 CRC64;
MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL AGCTFQDIIL
EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQVWFK
NRRAKFRKKQ RSLQKEQLQK QKDVSTDGAL AASDKDEAPS TLNLENQPPS STSSSSSMEA
EAAPHALGSE LSVELNVTSA EQSGSESATE DNATDKEEEI KQHREDLKVE KEPAPGNLSP
LCKRLSPKPD SPLGSPAISS SSSGVTGGIS QSHSYSSSPL SLFRLQEQFR QHMAATNNLV
HYPSFDMATP SSIPYLGMNV NMPAPLGSLP CQSYYQSLSH HAQQVWNSPL LQASGGLPSH
NSKTTSIENL RLRAKQHAAS LGLDTLPN
