ID   DMX1B_DANRE             Reviewed;         369 AA.
AC   Q566X8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Diencephalon/mesencephalon homeobox protein 1-B;
GN   Name=dmbx1b {ECO:0000312|ZFIN:ZDB-GENE-050417-97};
GN   Synonyms=mbx2 {ECO:0000312|EMBL:ABC47375.1}; ORFNames=zgc:112395;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABC47375.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic head {ECO:0000269|PubMed:16733737};
RX   PubMed=16733737; DOI=10.1007/s00427-006-0082-7;
RA   Chang L., Khoo B., Wong L., Tropepe V.;
RT   "Genomic sequence and spatiotemporal expression comparison of zebrafish
RT   mbx1 and its paralog, mbx2.";
RL   Dev. Genes Evol. 216:647-654(2006).
RN   [2] {ECO:0000312|EMBL:AAH93284.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000312|EMBL:AAH93284.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NFW5,
CC       ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-
CC       ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: In embryos, expressed in mesencephalon with
CC       strongest expression ventrally. In adult, expressed in midbrain.
CC       {ECO:0000269|PubMed:16733737}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed maternally. Low levels from 13-24
CC       hours post-fertilization (hpf). Also expressed in adult.
CC       {ECO:0000269|PubMed:16733737}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000255}.
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DR   EMBL; DQ317638; ABC47375.1; -; mRNA.
DR   EMBL; BC093284; AAH93284.1; -; mRNA.
DR   RefSeq; NP_001017625.1; NM_001017625.2.
DR   AlphaFoldDB; Q566X8; -.
DR   SMR; Q566X8; -.
DR   STRING; 7955.ENSDARP00000027542; -.
DR   PaxDb; Q566X8; -.
DR   Ensembl; ENSDART00000026693; ENSDARP00000027542; ENSDARG00000002510.
DR   GeneID; 550288; -.
DR   KEGG; dre:550288; -.
DR   CTD; 550288; -.
DR   ZFIN; ZDB-GENE-050417-97; dmbx1b.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000155505; -.
DR   HOGENOM; CLU_060969_0_0_1; -.
DR   InParanoid; Q566X8; -.
DR   OMA; LQCQSYY; -.
DR   OrthoDB; 1270742at2759; -.
DR   PhylomeDB; Q566X8; -.
DR   TreeFam; TF351609; -.
DR   PRO; PR:Q566X8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000002510; Expressed in sensory ganglion and 25 other tissues.
DR   ExpressionAtlas; Q566X8; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030901; P:midbrain development; IMP:ZFIN.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IGI:ZFIN.
DR   GO; GO:0061074; P:regulation of neural retina development; IGI:ZFIN.
DR   GO; GO:0050767; P:regulation of neurogenesis; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Diencephalon/mesencephalon homeobox protein 1-B"
FT                   /id="PRO_0000273272"
FT   DNA_BIND        66..125
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          124..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           346..359
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   COMPBIAS        126..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  40643 MW;  DC752C7730221261 CRC64;
     MQHYGVNGYS LHAMNSLSAM YNLHQQAAQH AQHAPDYRPS VHALTLAERL ADIILEARYG
     SQHRKQRRSR TAFTAQQLEA LEKTFQKTHY PDVVMRERLA MCTNLPEARV QVWFKNRRAK
     FRKKQRSLQK EQLQRLKEAG TEGAQDEGKE EAPPVEAQAP PSPLDGRGLT SAPSCELNEE
     VNVTSPEQSG AESGAEDTTD REDEPLSIKD EIKEAGPPLM TDDSSPSYKP LSPKSDDPLV
     SPALPSSSGA VAQSNSYASS PLSLFRLQEQ FRQHMAATNN LMHYPAFDVT APSSLPYLGV
     NVNMASPLGS LPCQPYYQTL TQAQQMWSSP LLQGSGGLPA LNSKTTSIEN LRLRAKQHAA
     SLGLDTLPN