DMXL1_MOUSE
ID DMXL1_MOUSE Reviewed; 3013 AA.
AC Q6PNC0; Q3TLG8; Q6PHM6; Q8BQF2;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=DmX-like protein 1;
DE Short=X-like 1 protein;
GN Name=Dmxl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv; TISSUE=Embryonic stem cell;
RA Bikar S.E., Kraemer C., Schmidt E.R.;
RT "Mus musculus mRNA for Dmx-like 1 protein.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1916-3013.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2719-3013.
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420; SER-423; SER-434;
RP SER-572; SER-916; SER-922; SER-1903 AND SER-1965, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE38824.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY590892; AAT01618.1; -; mRNA.
DR EMBL; BC056490; AAH56490.1; -; mRNA.
DR EMBL; AK050888; BAC34446.1; -; mRNA.
DR EMBL; AK166520; BAE38824.1; ALT_INIT; mRNA.
DR CCDS; CCDS37816.2; -.
DR RefSeq; NP_001074840.2; NM_001081371.2.
DR BioGRID; 232188; 4.
DR IntAct; Q6PNC0; 1.
DR MINT; Q6PNC0; -.
DR STRING; 10090.ENSMUSP00000045559; -.
DR iPTMnet; Q6PNC0; -.
DR PhosphoSitePlus; Q6PNC0; -.
DR EPD; Q6PNC0; -.
DR jPOST; Q6PNC0; -.
DR MaxQB; Q6PNC0; -.
DR PaxDb; Q6PNC0; -.
DR PRIDE; Q6PNC0; -.
DR ProteomicsDB; 279737; -.
DR Antibodypedia; 49471; 26 antibodies from 13 providers.
DR Ensembl; ENSMUST00000180611; ENSMUSP00000137871; ENSMUSG00000037416.
DR GeneID; 240283; -.
DR KEGG; mmu:240283; -.
DR UCSC; uc008ewo.2; mouse.
DR CTD; 1657; -.
DR MGI; MGI:2443926; Dmxl1.
DR VEuPathDB; HostDB:ENSMUSG00000037416; -.
DR eggNOG; KOG1064; Eukaryota.
DR GeneTree; ENSGT00390000000096; -.
DR HOGENOM; CLU_000267_0_0_1; -.
DR InParanoid; Q6PNC0; -.
DR OMA; HPDSQSN; -.
DR OrthoDB; 127808at2759; -.
DR PhylomeDB; Q6PNC0; -.
DR BioGRID-ORCS; 240283; 6 hits in 69 CRISPR screens.
DR ChiTaRS; Dmxl1; mouse.
DR PRO; PR:Q6PNC0; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q6PNC0; protein.
DR Bgee; ENSMUSG00000037416; Expressed in epithelium of small intestine and 250 other tissues.
DR ExpressionAtlas; Q6PNC0; baseline and differential.
DR Genevisible; Q6PNC0; MM.
DR GO; GO:0043291; C:RAVE complex; IBA:GO_Central.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR022033; Rav1p_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12234; Rav1p_C; 2.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..3013
FT /note="DmX-like protein 1"
FT /id="PRO_0000223323"
FT REPEAT 108..145
FT /note="WD 1"
FT REPEAT 164..204
FT /note="WD 2"
FT REPEAT 227..275
FT /note="WD 3"
FT REPEAT 474..514
FT /note="WD 4"
FT REPEAT 578..619
FT /note="WD 5"
FT REPEAT 842..893
FT /note="WD 6"
FT REPEAT 970..1008
FT /note="WD 7"
FT REPEAT 1145..1193
FT /note="WD 8"
FT REPEAT 1208..1248
FT /note="WD 9"
FT REPEAT 2728..2769
FT /note="WD 10"
FT REPEAT 2771..2810
FT /note="WD 11"
FT REPEAT 2822..2864
FT /note="WD 12"
FT REPEAT 2870..2909
FT /note="WD 13"
FT REPEAT 2912..2951
FT /note="WD 14"
FT REPEAT 2964..3002
FT /note="WD 15"
FT REGION 418..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2364..2406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2431..2462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2439..2455
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y485"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 423
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 434
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 572
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 916
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 922
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1829
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y485"
FT MOD_RES 1896
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y485"
FT MOD_RES 1903
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1965
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 2812
FT /note="S -> N (in Ref. 3; BAE38824)"
FT /evidence="ECO:0000305"
FT CONFLICT 2944
FT /note="S -> L (in Ref. 3; BAE38824)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3013 AA; 336008 MW; 3C57BD3218EE748D CRC64;
MNLHQVLTGA VNPGDHCFAV GSVGEQRFTA YASGCDIVIL GSNFERLQII PGAKHGNIQV
GCVDCSMQQG KIAASYGNVI SVFEPVSLPK KRKNLEFYSQ WQKSGQFFLD SIAHNITWDP
AGNRLLTGSS CLQLWCNSRK QTEDENPDKT DLNFGNWMCI WHCKTASQVH LMKFSPDGEF
FATAGKDDCL LKVWYNVENW RPAVTSPDKN SEKQSQGEID FSFVYLAHPR AVNGFSWRKT
SKYMPRASVC NVLLTCCKDN VCRLWVETFL PNDCFLYGSD CNHWCEPVSL TNNLKRNASS
KDRVQSALEV NLRPFRRGRS RSLALVAHTG YLPHQQDPHH AHRNTPLHAN ALCHFHIAAS
INPATDIPLL PSITSLSLNE NEEKCGPFVV HWLNNKELHF TLSMEVFLQQ LRKSFEQPSS
EASVEDSIQA DLKSDEELDD GVDDLKINHE KKELDEDKML PSSSFTPLSS AAVDHQIEVL
LSEWSKNADM LFSIHPMDGS LLVWHVDWLD EYQPGMFRQV QVSFVSRIPV AFPTGDANSL
CKSIVMYACT KNVDLAIQQG KQRPTGLTRS TSMLISSAHS KSSNNLKLSI FTPNVMMISK
HADGSLNQWL VSFAEESAFS TVLSISHKSR YCGHRFHLND LACHSVLPLL LTTSHHNALR
TPNVGNQKQA HDAVNTEECS LAQQNKSNVD MAFQDPNAIY SELILWRVDP VGPLSFSGGV
SELARINSLH VSAFSNVAWL PTLIPSYCLG AYCNSPSACF VASDGQYLRL YEAVIDAKKL
LYELSNPEIS KYVGEVFNIV SQQSTARPGC IIALDSITKL HGRKTQLLHV FQEDFILNNL
EKKRLGVDNI LLDSDSSCNG FSEKFYLVVI ECTEDNRSLL RMWDLHLRST PVSLDERIDT
KISEASWLPE EHYSSSPEKI LSPFSQKFQA CRANLQSTSK LSLFSEMVYS KELDLPEGVE
IISVKPSAGH LSSSSIYPVC SAPYLLATSC SDDKVRFWRC RVTNGESATS KNGKLDVVYV
WEEWPLLIED GLENNSSVTV PGRPVEVSCA HTSRLAVAYK QPTGNSRSQE FVMHVSIFEC
ESTGGSCWIL EQTIHLDELS TVLDSGISID SNLVAYNKQE TYLVSKESIT SNTKHLVHLD
WMSREDGSHI LTVGIGSKLF MYGPMAGKVQ DQTGKENQAF PLWDSTKIVP LSKFVLLRSV
DLVSSVEGAP PFPVSLSWVR DGILVVGMDC EMHVYSQWQP SNKQEPVISE SYNGSTPSIL
SLIKQSNSSS SGLHPPKKTL TRSMTSLAQK ICGKKSIFDP SVDMEDSGLF EAAHVLSPTL
PQYHPLQLLE LMDLGKVRRA KAILSHLVKC IAGEVVALNE AESNHERRLR SLTISASGST
TRDPQAFNKA DSRDYTEIDS VPPLPLYALL AADDDSYCSS LEKTGSESSL KKSKQLSKES
YDELFQTSVL MSDNHMLETD EENTQPRVID LSQYSPTYFG PEHAQVLSGH LLHSSLPGLT
RMEQMSLMAL ADTIATTSTD IGESRDRNQG GETLDECGLK FLLAVRLHTF LTTSLPAYRA
QLLHQGLSTG HFAWAFHSVA EEELLNMLPA MQKDDPTWSE LRAMGVGWWV RNARILRRCI
EKVAKAAFHR NNDPLDAAIF YLAMKKKAVI WGLYRSQKDT KMTQFFGHNF EEERWRKAAL
KNAFSLLGKQ RFEHSAAFFL LGGCLKDAIE VCLEKLNDIQ LALVIARLFE SEFDKSATYK
SILRKKVLGI GSPASELSSS SINAHHDPFL RSMAHWILED YSAALETLIK QPVTEDEDQV
MMSACNPIVF NFYNYLRTHP LLLRRHFGSS SETFSTHMTL AGKSGLAGTI NLSERRLFFT
TASAHLKAGC PMLALEVLSK MPKVSKKAKP CCRGSSFLTS KDSSLKLDVR EDKCCAADWS
PSLTNGLESS SEGSSERHSH STLSFDWSQP SVVFQDDSLE LKWDSDNDEE NEDPPISMKE
IRPLQRKTVK EIDELSSYTD SLSTLDENDI LNPSEDIIAV QLKFRACLKI LTVELRTLST
GYEIDGGKLR YQLYHWLEKE VVALQRTCDF CSDADQLQTT FSQSADESGS TEDADDLHHQ
TKVKQLRESF QEKRQWLLKY QSLLRMFLSY CVLHGSHGGG LASVRMELIL LLQESQQETA
EPIFSNPLSE QTSVPLLFAC TASAKTVVAN PLLHLSNLTH DILHAIINFD SPPHPDSQTN
KVYVMHTLAA SLSACIYQCL CGSHNYSSFQ TNQFTGMVYQ TVLLAHRHSL RTGSLDESVT
PNTSPAQWPG INFLIQLLNS SGEEAQSGLT VLLCEILTAV YLSLFIHGLA THSSNELFRI
VAHPLNEKMW SAVFGGGAHV PSKGQANSKA LSVEGEKQNR HISPSKVSAR ESPVSSSSGN
QEPPAVKEKF VPPELSIWDY FIAKPFLPPS QSRAEYDSEE SLESDDEEEE DDDDALPSGL
QLHEHSNSNS FSWSLMRLAM VQLVLNNLKT FYPFAGHDLA ELPVSSPLCH AVLKTLQCWE
QVLLRRLEIH GGPPQNYISS HTSEENVSAG PAILRHKALL EPTNTPFKSK NHLALSVKRL
WQYLVKQEEI QETFIRNIFT KKRCLNEIEA DLGYPGGKAR IIHKESDIIT AFAVNRANRN
CIAIASSHDV QELDVSAILA TQIYTWVDDD TETETKGSED FLVIHARDDL SAVQGSTPYT
HSNPGTPINM PWLGSTQTGR GASVMLKKAI NNVRRMTSHP TLPYYLTGAQ DGSVRMFEWG
HSQQITCFRS GGNSRITRMR FNYQGNKFGI VDADGYLSLY QTNWKCCPVT GSMPKPYLAW
QCHNKTANDF VFVSSSSLIA TAGLSSDNRN ICLWDTLVAP ANSLVHAFTC HDSGATVLAY
APKHQLLISG GRKGFTCIFD LRQRQQRQLF QSHDSPVKAI AIDPTEEYFV TGSAEGNIKI
WSLSSFSLLH TFINEHARQS IFRNIGTGVM QIETGPANHI FSCGADGTMK MRILPDQFSP
LNEVLKNDVK FML
