DMXL2_MOUSE
ID DMXL2_MOUSE Reviewed; 3032 AA.
AC Q8BPN8; B0V2P4; Q3TNY5; Q69ZX5; Q8CCU3;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=DmX-like protein 2;
DE AltName: Full=Rabconnectin-3;
GN Name=Dmxl2; Synonyms=Kiaa0856;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-1485 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Eye, Head, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1224-2891 (ISOFORM 2).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326; SER-587; SER-945;
RP SER-946; SER-1141; SER-1144; SER-1288; THR-1416; SER-1856; THR-2017;
RP SER-2394 AND SER-2636, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25248098; DOI=10.1371/journal.pbio.1001952;
RA Tata B., Huijbregts L., Jacquier S., Csaba Z., Genin E., Meyer V., Leka S.,
RA Dupont J., Charles P., Chevenne D., Carel J.C., Leger J., de Roux N.;
RT "Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes
RT infertility associated with a loss of GnRH neurons in mouse.";
RL PLoS Biol. 12:E1001952-E1001952(2014).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=27657680; DOI=10.1038/gim.2016.142;
RA Chen D.Y., Liu X.F., Lin X.J., Zhang D., Chai Y.C., Yu D.H., Sun C.L.,
RA Wang X.L., Zhu W.D., Chen Y., Sun L.H., Wang X.W., Shi F.X., Huang Z.W.,
RA Yang T., Wu H.;
RT "A dominant variant in DMXL2 is linked to nonsyndromic hearing loss.";
RL Genet. Med. 19:553-558(2017).
CC -!- FUNCTION: May serve as a scaffold protein for MADD and RAB3GA on
CC synaptic vesicles of neuronal and endocrine homeostatic processes (By
CC similarity). Plays a role in the brain as a key controller of neuronal
CC and endocrine homeostatic processes (PubMed:25248098).
CC {ECO:0000250|UniProtKB:Q8TDJ6, ECO:0000269|PubMed:25248098}.
CC -!- SUBUNIT: Interacts with MADD and RAB3GAP.
CC {ECO:0000250|UniProtKB:Q8TDJ6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250|UniProtKB:Q8TDJ6}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:Q8TDJ6}. Cytoplasmic vesicle, secretory
CC vesicle, neuronal dense core vesicle {ECO:0000269|PubMed:25248098}.
CC Note=The external layer of the inferior boundary for the hypothalamus
CC part of the human brain (the so called median eminence (ME)) displayed
CC a punctate pattern of expression; expression also observed in the cell
CC bodies lining the third ventricle, in the long processes extending from
CC these cell bodies toward the external layer of the ME, in small clear
CC vesicles, and in large dense core vesicles.
CC {ECO:0000269|PubMed:25248098}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BPN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BPN8-2; Sequence=VSP_026596, VSP_026597;
CC Name=3;
CC IsoId=Q8BPN8-3; Sequence=VSP_026594, VSP_026595;
CC -!- TISSUE SPECIFICITY: Expressed in the brain and pituitary gland.
CC Detected in the hippocampus, dentate gyrus, hypothalamus, pyriform
CC cortex and the granular and molecular layers of the cerebellum of adult
CC animals. In the hypothalamus, expression is observed in the arcuate
CC nucleus, the ME, the organum vasculosum of the lamina terminalis, and
CC the subfornical organ, the subcommissural organ, and the
CC suprachiasmatic nucleus. Both tanycytes and hypothalamic neurosecretory
CC neurons express the protein (PubMed:25248098). Expressed in the inner
CC and outer hair cells as well as in the spiral ganglion neurons
CC (PubMed:27657680). Expressed in insulin-secreting cells of the islets
CC of Langerhans in the pancreas (PubMed:25248098).
CC {ECO:0000269|PubMed:25248098, ECO:0000269|PubMed:27657680}.
CC -!- DISRUPTION PHENOTYPE: Conditional heterozygous deletion of the gene in
CC neurons causes delayed puberty as well as very low fertility; the
CC reproductive phenotype is associated with a reduced number of GnRH
CC neurons in the hypothalamus of adult mice. Animals with a homozygous
CC deletion of the gene die during embryonic development.
CC {ECO:0000269|PubMed:25248098}.
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DR EMBL; AK032099; BAC27698.1; -; mRNA.
DR EMBL; AK053672; BAC35468.2; -; mRNA.
DR EMBL; AK164884; BAE37952.1; -; mRNA.
DR EMBL; AC161589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT010507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK173043; BAD32321.1; -; Transcribed_RNA.
DR RefSeq; XP_006511148.2; XM_006511085.3. [Q8BPN8-1]
DR IntAct; Q8BPN8; 15.
DR MINT; Q8BPN8; -.
DR STRING; 10090.ENSMUSP00000113705; -.
DR iPTMnet; Q8BPN8; -.
DR PhosphoSitePlus; Q8BPN8; -.
DR SwissPalm; Q8BPN8; -.
DR MaxQB; Q8BPN8; -.
DR PaxDb; Q8BPN8; -.
DR PeptideAtlas; Q8BPN8; -.
DR PRIDE; Q8BPN8; -.
DR ProteomicsDB; 279790; -. [Q8BPN8-1]
DR ProteomicsDB; 279791; -. [Q8BPN8-2]
DR ProteomicsDB; 279792; -. [Q8BPN8-3]
DR Antibodypedia; 51332; 60 antibodies from 16 providers.
DR Ensembl; ENSMUST00000118600; ENSMUSP00000113693; ENSMUSG00000041268. [Q8BPN8-1]
DR GeneID; 235380; -.
DR UCSC; uc009prb.1; mouse. [Q8BPN8-3]
DR CTD; 23312; -.
DR MGI; MGI:2444630; Dmxl2.
DR VEuPathDB; HostDB:ENSMUSG00000041268; -.
DR eggNOG; KOG1064; Eukaryota.
DR GeneTree; ENSGT00390000000096; -.
DR HOGENOM; CLU_000267_0_0_1; -.
DR InParanoid; Q8BPN8; -.
DR PhylomeDB; Q8BPN8; -.
DR BioGRID-ORCS; 235380; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Dmxl2; mouse.
DR PRO; PR:Q8BPN8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BPN8; protein.
DR Bgee; ENSMUSG00000041268; Expressed in superior cervical ganglion and 228 other tissues.
DR ExpressionAtlas; Q8BPN8; baseline and differential.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098992; C:neuronal dense core vesicle; IDA:SynGO.
DR GO; GO:0043291; C:RAVE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IMP:MGI.
DR GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
DR GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR022033; Rav1p_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12234; Rav1p_C; 2.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasmic vesicle; Membrane;
KW Phosphoprotein; Reference proteome; Repeat; Synapse; WD repeat.
FT CHAIN 1..3032
FT /note="DmX-like protein 2"
FT /id="PRO_0000223325"
FT REPEAT 108..145
FT /note="WD 1"
FT REPEAT 167..207
FT /note="WD 2"
FT REPEAT 230..278
FT /note="WD 3"
FT REPEAT 492..532
FT /note="WD 4"
FT REPEAT 594..633
FT /note="WD 5"
FT REPEAT 750..802
FT /note="WD 6"
FT REPEAT 879..921
FT /note="WD 7"
FT REPEAT 1001..1038
FT /note="WD 8"
FT REPEAT 1164..1205
FT /note="WD 9"
FT REPEAT 1245..1285
FT /note="WD 10"
FT REPEAT 2757..2796
FT /note="WD 11"
FT REPEAT 2800..2839
FT /note="WD 12"
FT REPEAT 2846..2888
FT /note="WD 13"
FT REPEAT 2894..2933
FT /note="WD 14"
FT REPEAT 2936..2975
FT /note="WD 15"
FT REPEAT 2988..3026
FT /note="WD 16"
FT REGION 418..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1922..1953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2722..2744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2117..2146
FT /evidence="ECO:0000255"
FT COMPBIAS 433..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 473
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TDJ6"
FT MOD_RES 587
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 945
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 946
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1141
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1144
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TDJ6"
FT MOD_RES 1288
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1399
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TDJ6"
FT MOD_RES 1416
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1856
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2017
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2394
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2636
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 923..933
FT /note="AKAAEGISSDS -> GKKLYCYFIQR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026594"
FT VAR_SEQ 934..3032
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026595"
FT VAR_SEQ 2272
FT /note="Y -> YS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_026596"
FT VAR_SEQ 2488..2498
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_026597"
FT CONFLICT 655
FT /note="L -> P (in Ref. 1; BAC35468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3032 AA; 338209 MW; 2FB99AE184E56207 CRC64;
MHLHQVLTGA VNPGDNCYSV GSVGDVPFTA YGSGCDIVIL ASDFECVQII PGAKHGNIQV
SCVECSNQHG RVAASYGNAV CIFEPLGVNS HKRNSQLKCQ WLKTGQFFLS SVTYNLAWDP
QDNRLLTATD SIQLWAPPGG DILEEEEDVD NRAPPVLNDW KCIWQCKTSV SVHLMEWSPD
GEYFATAGKD DCLLKVWYPM TGWKSSIIPQ DPHEVKRRRA STQFSFVYLA HPRAVTGFSW
RKTSKYMPRG SVCNVLLTSC HDGVCRLWAE TLLPEDCLLG EQICETTTSS VASNLSSAGK
HKDRIQHALE TIHHLKNLRK GQRRSSVLVT HAELMPDKTA THEVHRHISH HANALCHFHI
AASINPTTDI PNVLVGTAFN IDDINGGFVV HWLNNKEFHF TSSTEIFMHQ LRKLSEKQLD
HESDDADRED EERSQDERER GLRMKLDHEL SLDRESEAGT GSSEHEDGER EGSPRTHPRP
SISMPLPTVL LDRKIETLLT EWNKNPDMLF TIHPVDGTFL VWHVKYLDEY NPGIFRQVQV
SFSSRIPVAF PSGDANSLSK NIMMYACVNA TKDSYNPSQQ EMMSVDSPHG SQLHSPSHST
DMNILAPTVM MVSKHIDGSL NQWAVTFADK SAFTTVLTVS HKFRYCGHRF HLNDLACHSV
LPLLLTSSHH NALLTPESDC QWDSDSKVNR LIDPVKHTKA SSKQPLRNAA TRTFHDPNAI
YSELILWRVD PIGPLSYTGG VSELARINSL HTSAFSNVAW LPTLIPSYCL GTYCNSASAC
FVASDGKNLR LYQAVVDARK LLDELSDPEA SKLIGEVFNI VSQQSTARPG CIIELDAITD
QCGSNTQLLH VFQEDFIIGY KPHKEDMEKK EKESEIFFQP SQGYRPPPFS EKFFLVVIEK
DGNNNSILHM WHLHLKSVQA CLAKAAEGIS SDSLLSVPGQ KNLDSSPETS SSMSSVPHSS
SIANLQTASK LILSSRLVYS QPLDLPEAVE VIRATPSAGH LSSSSIYPVC LAPYLVVTTC
SDNKVRFWKC CMETNSLGNT SDESETYHWR RWPLMNDEGE DNSSTVSIVG RPVAVSCSYT
GRLAVAYKQP IHHNGFISKE FSMHVCIFEC ESTGGSEWVL EQTIHLDDLV KVGSVLDSRV
SVDSNLFVYS KSDAFLSKDR YLIPNIKHLV HLDWVSKEDG SHILTVGVGA NIFMYGRLSG
IVSDQTNSKD GVAVITLPLG GSIKQGVKSR WVLLRSIDLV SSVDGTPSLP VSLSWVRDGI
LVVGMDCEMH VYAQWKHSVK FGNVDADSPV EETIQDHSAL KSSMLARKSI VEGAAIPDDV
FCSPTVVQDG GLFEAAHALS PTLPQYHPTQ LLELMDLGKV RRAKAILSHL VKCIAGEVAI
VRDPDAGEGT KRHLSRTISV SGSTAKDTVT IGKDGTRDYT EIDSIPPLPL HALLAADQDT
SYRISEDSTK KPQSYEDHIE SQSEDQYSEL FQVQEITTDD IDLEPEKREN KSKVINLSQY
GPACFGQEHA RVLSSHLMHS SLPGLTRLEQ MFLVALADTV ATTSTELDEN RDKNYSGRDT
LDECGLRYLL AMRLHTCLLT SLPPLYRVQL LHQGVSTCHF AWAFHSEAEE ELINMIPAIQ
RGDPQWSELR AMGIGWWVRN VNTLRRCIEK VAKAAFQRNN EALDAALFYL SMKKKAVVWG
LFRSQHDEKM TTFFSHNFNE DRWRKAALKN AFSLLGKQRF EQSAAFFLLA GSLKDAIEVC
LEKMEDIQLA MVIARLFESE FETSSTYISI LNQKILGCQK DGTGFDCKRL HPDPFLRSLA
YWVVKDYTRA LDTLLEQTPK EDDEQQVIIK SCNPVVFSFY NYLRTHPLLI RRNLASPEGT
LATLGLKTEK NIADKINLIE RKLFFTTANA HFKVGCPVLA LEVLSKIPKV TKISSLTAKK
DQLDSVSGRM ENGPSESKPV SRSDGGSGAD WSAVTSSQFD WSQPMVTVDE EPLRLDWGDD
HDGALEEDDG GGLVMKTTDA KKAGQEQSAS DPRALLTPQD EECADGDTEV DVIAEQLKFR
ACLKILMTEL RTLATGYEVD GGKLRFQLYN WLEKEIAALH EICNHESVIK EYSSKAHSTV
ETERLDQEEM VDKPDIGSYE RHQIERRRLQ AKREHAERRK LWLQKNQDLL RVFLSYCSLH
GAQGGGLASV RMELKFLLQE SQQETTVKQL QSPLPLPTTL PLLSASIAST KTVIANPVLY
LNNHIHDILY TIVQMKTPPH PSVEDVKVHT LHSLAASLSA SIYQALCDSH SYSQSEGNQF
TGMAYQGLLL SDRRRLRTES IEEHATPNSA PAQWPGVSSL INLLSSAQDE DQPKLNVLLC
EAVVAVYLSL LIHALATNSS NELFRLAAHP LNNRMWAAVF GGGVKLVVKP RRQSESIAAP
PVASEDMDKH RRRFNMRMLV PGRPVKDATP PPVPAERPSY KEKFIPPELS MWDYFVAKPF
LPLSDSGVIY DSDESVHSDD EEDDAFFSDT QIQEHQDPNS YSWALLHLTM VKLALHNIKN
FFPIAGLEFS ELPVTSPLGI AVIKNLENWE QILQEKMDHF EGPPPNYVNT YPTDLSVGAG
PAILRNKAML EPENTPFKSR DSSALPVKRL WHFLVKQEVL QETFIRYIFT KKRKQSEVEA
DLGYPGGKAK VIHKESDMIM AFSINKANCN EIVLASTHDV QELDVTSLLA CQSYIWIGEE
YDRESKSSDD IDYRGSTTTL YQPGAASHSS SQPHPPPSLP WLGSGQTSTG ATVLMKRNLH
NVKRMTSHPV HQYYLTGAQD GSVRMFEWTR PQQLVCFRQA GNARVTRLYF NSQGNKCGVA
DGEGFLSIWQ VNQTASNPKP YMSWQCHSKA TSDFAFITSS SLVATSGHSN DNRNVCLWDT
LISPGNSLIH GFTCHDHGAT VLQYAPKQQL LISGGRKGYI CIFDIRQRQL IHTFQAHDSA
IKALALDSCE EYFTTGSAEG NIKVWRLTGH GLIHSFKSEH AKQSIFRNIG AGVMQIAISQ
DNRLFSCGAD GTLKTRVLPS AFNIPNRILD IL
