DN7C_ACIHW
ID DN7C_ACIHW Reviewed; 60 AA.
AC F4B8X5;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=DNA-binding protein 7c {ECO:0000305};
DE AltName: Full=7 kDa DNA-binding protein c {ECO:0000305};
DE AltName: Full=Aho7c {ECO:0000303|PubMed:27853299};
GN OrderedLocusNames=Ahos_0959 {ECO:0000312|EMBL:AEE93845.1};
OS Acidianus hospitalis (strain W1).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=933801;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1;
RX PubMed=21607549; DOI=10.1007/s00792-011-0379-y;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA She Q., Liu S.J., Garrett R.A.;
RT "Genomic analysis of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 15:487-497(2011).
RN [2]
RP DNA-BINDING, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, SUBCELLULAR LOCATION,
RP AND NOMENCLATURE.
RX PubMed=27853299; DOI=10.1038/srep37274;
RA Kalichuk V., Behar G., Renodon-Corniere A., Danovski G., Obal G.,
RA Barbet J., Mouratou B., Pecorari F.;
RT "The archaeal '7 kDa DNA-binding' proteins: extended characterization of an
RT old gifted family.";
RL Sci. Rep. 6:37274-37274(2016).
CC -!- FUNCTION: Can constrain negative DNA supercoils. May be involved in
CC maintaining the integrity of the genome at high temperature.
CC {ECO:0000250|UniProtKB:P61990}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Highly stable from pH 0 to pH 12. {ECO:0000269|PubMed:27853299};
CC Temperature dependence:
CC Hyperthermostable. {ECO:0000269|PubMed:27853299};
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:27853299}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27853299}.
CC -!- SIMILARITY: Belongs to the 7 kDa DNA-binding/endoribonuclease P2
CC family. {ECO:0000305}.
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DR EMBL; CP002535; AEE93845.1; -; Genomic_DNA.
DR RefSeq; WP_013775761.1; NC_015518.1.
DR AlphaFoldDB; F4B8X5; -.
DR SMR; F4B8X5; -.
DR STRING; 933801.Ahos_0959; -.
DR EnsemblBacteria; AEE93845; AEE93845; Ahos_0959.
DR GeneID; 42780608; -.
DR KEGG; aho:Ahos_0959; -.
DR eggNOG; arCOG05888; Archaea.
DR HOGENOM; CLU_2929990_0_0_2; -.
DR OrthoDB; 128098at2157; -.
DR Proteomes; UP000008458; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR003212; DNA-bd_7kDa_arc.
DR Pfam; PF02294; 7kD_DNA_binding; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Reference proteome.
FT CHAIN 1..60
FT /note="DNA-binding protein 7c"
FT /id="PRO_0000439047"
FT REGION 37..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 60 AA; 6878 MW; 89659271BB3E8857 CRC64;
MATKVKFKYK GEEKEVDISK IKKVWRVGKM ISFTYDDNGK TGRGAVSEKD APKELLEKLK