DNAA1_CHLCV
ID DNAA1_CHLCV Reviewed; 450 AA.
AC Q823P0;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Chromosomal replication initiator protein DnaA 1;
GN Name=dnaA1; Synonyms=dnaA-1; OrderedLocusNames=CCA_00368;
OS Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS (Chlamydophila caviae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=227941;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX PubMed=12682364; DOI=10.1093/nar/gkg321;
RA Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA Fraser C.M.;
RT "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT examining the role of niche-specific genes in the evolution of the
RT Chlamydiaceae.";
RL Nucleic Acids Res. 31:2134-2147(2003).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR EMBL; AE015925; AAP05115.1; -; Genomic_DNA.
DR RefSeq; WP_011006332.1; NC_003361.3.
DR AlphaFoldDB; Q823P0; -.
DR SMR; Q823P0; -.
DR STRING; 227941.CCA_00368; -.
DR EnsemblBacteria; AAP05115; AAP05115; CCA_00368.
DR KEGG; cca:CCA_00368; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_1_0; -.
DR OMA; FPAFKIV; -.
DR OrthoDB; 219876at2; -.
DR Proteomes; UP000002193; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..450
FT /note="Chromosomal replication initiator protein DnaA 1"
FT /id="PRO_0000114155"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 51100 MW; CF440A7B300210D8 CRC64;
MLTCSDCSTW EQFVNYVKTR CSKTAFENWI SPIQIIEETQ EKIRLEVPNI FVQNYLLDNY
KQDLCSFVPL DAQGEPALEF VVAEIKKAPA QPIAPREPQE SPAETFEESK DFELKLNAAY
RFDNFIEGPS NQFVKSAAVG IAGRPGRSYN PLFIHGGVGL GKTHLLHAVG HYVREHHKNL
RVHCITTEAF INDLVQHLRL KSIDKMKNFY RSLDLLLVDD IQFLQNRQNF EEEFCNTFET
LINLNKQIVI TSDKPPGQLK LSERIIARME WGLVAHVGIP DLETRVAILQ HKAEQKGLHI
PNEIAFYIAD HIYGNVRQLE GAINKLTAYC RLFGKTLTES IVRDTLRELF RSPSKQKVSV
ESILKSVATV FQVKLQDLKG TSRSKELVLA RQVAMYLAKT LITDSLVAIG SAFGKTHSTV
LYACKTIEQK IEKDETLTRQ ISLCKNHIVG