ID   DNAA1_CHLMU             Reviewed;         456 AA.
AC   Q9PKE4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 1;
GN   Name=dnaA1; OrderedLocusNames=TC_0521;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AE002160; AAF39363.1; -; Genomic_DNA.
DR   PIR; F81692; F81692.
DR   RefSeq; WP_010230675.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PKE4; -.
DR   SMR; Q9PKE4; -.
DR   STRING; 243161.TC_0521; -.
DR   EnsemblBacteria; AAF39363; AAF39363; TC_0521.
DR   GeneID; 1245881; -.
DR   KEGG; cmu:TC_0521; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_0; -.
DR   OMA; HINFICK; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..456
FT                   /note="Chromosomal replication initiator protein DnaA 1"
FT                   /id="PRO_0000114157"
FT   BINDING         147..154
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  51937 MW;  9B538CF91250B364 CRC64;
     MRAWEEFLLL QEKEIGTDTV NKWLRSLKVL CFDACNLYLE AKDSFQVTWF EEHIRHKVKA
     NLINNNGKPI RVRVTSLDKS TPFKESQIQQ EKTAYFTMQY GDIDPQMSFA NFLVTPENDL
     PVRILQEFAK VSEQGKGFPF NPIYLFGPES SGKTHLMQAA VGILREAGVK TLYVSSQLFT
     EHLVSAIRSG EMQRFRAFYR NVEALFIEDI EVLSGKGATQ EEFFHTFNSL HTEGKLIVIS
     SIFAPGDLKA MEERLISRFE WGIAVPVSPL TREGLKSFLE RRIEQLNIRI EETALDFLIQ
     ALSSHIKSLL HALTTLAKRV AYKKLSHQLL YQGDVEALLQ DVLQAAEHIR LTPSGIVRAT
     AQYYGVSPEN ILGRSQSREY VLPRQVAMFL CRQKLSLSYV KIGEVFSRDH STVISSIRAI
     SQKLDEDDRE SDVSCGVQEL TKRLSSAYQS LDLIVD