ID   DNAA1_CHLTR             Reviewed;         456 AA.
AC   O84252;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 1;
GN   Name=dnaA1; OrderedLocusNames=CT_250;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67843.1; -; Genomic_DNA.
DR   PIR; D71537; D71537.
DR   RefSeq; NP_219755.1; NC_000117.1.
DR   RefSeq; WP_009871597.1; NC_000117.1.
DR   AlphaFoldDB; O84252; -.
DR   SMR; O84252; -.
DR   STRING; 813.O172_01355; -.
DR   EnsemblBacteria; AAC67843; AAC67843; CT_250.
DR   GeneID; 884874; -.
DR   KEGG; ctr:CT_250; -.
DR   PATRIC; fig|272561.5.peg.267; -.
DR   HOGENOM; CLU_026910_3_2_0; -.
DR   InParanoid; O84252; -.
DR   OMA; HINFICK; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..456
FT                   /note="Chromosomal replication initiator protein DnaA 1"
FT                   /id="PRO_0000114162"
FT   BINDING         147..154
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  51996 MW;  50C7E6FD28B47DFC CRC64;
     MRAWEEFLLL QEKEIGVDTV NKWLRSLKVL CFDACNLYLE AKDSFQVTWF EEHIRHKVKA
     SLINNNGKPI RVRVTSLDKS TPFKETQIQQ EKTAYFTMKY GDIDPNMSFA NFLVTPENDL
     PVRILQEFAK VSEQGKGFPF NPIYLFGPES SGKTHLMQAA VGGLREAGVK TLYVTSELFT
     EHLVSAIRSG EMQRFRAFYR NVEALFIEDI EVLSGKGATQ EEFFHTFNSL HTEGKLIVIS
     STFAPGDLKA MEERLISRFE WGISIPVSPL IREGLKSFLE RRTEKLNIRI EETALDFLIQ
     ALSSHVKSLL HALTTLAKRV AYKKLSHQML YQGDIEALLH DVLQAAESIR LTPSGIVRAT
     AQYYGVSPES VLGRSQSREY VLPRQVAMFL CRQKLSLSYV KIGEVFSRDH STVISSIRAI
     SQKLEEDDRE CDVSRAIQEL TKRLSSAYQS LDFIED