ID   DNAA1_PARUW             Reviewed;         451 AA.
AC   Q6MC93;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 1 {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA1 {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=pc1082;
OS   Protochlamydia amoebophila (strain UWE25).
OC   Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC   Candidatus Protochlamydia.
OX   NCBI_TaxID=264201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWE25;
RX   PubMed=15073324; DOI=10.1126/science.1096330;
RA   Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA   Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA   Mewes H.-W., Wagner M.;
RT   "Illuminating the evolutionary history of chlamydiae.";
RL   Science 304:728-730(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; BX908798; CAF23806.1; -; Genomic_DNA.
DR   RefSeq; WP_011175632.1; NC_005861.1.
DR   AlphaFoldDB; Q6MC93; -.
DR   SMR; Q6MC93; -.
DR   STRING; 264201.pc1082; -.
DR   EnsemblBacteria; CAF23806; CAF23806; PC_RS05215.
DR   KEGG; pcu:PC_RS05215; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_2_0; -.
DR   OMA; HINFICK; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000000529; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..451
FT                   /note="Chromosomal replication initiator protein DnaA 1"
FT                   /id="PRO_0000114226"
FT   BINDING         153..160
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   451 AA;  51317 MW;  13E6D8068992BA43 CRC64;
     MQAWEEFLKA QEVELGLETV QKWLRTLKIQ RFDACNLYLE AKDSFQALWF EEHIRNKAQQ
     KFINGNNKRI KIHLSVANTP QRAKKTKTAN KEKDFKAPFE LTFDELDPLC LFPYFISTEE
     NLLSHQLLLE IAGLSPQIHS TQLGTFNPIY LYGSGGSGKT HLLMSLAHAL KAQGLKVIYV
     RAETFTDHVV TAIRAGEMSV FRQAYRNIDV LLVDDVHVFS RKGATQEEFF HTFNTLHLEG
     KQIILASECS PQDLQLIEPR LVSRFEWGIV LPLKPLRPGE MRNLLIAKAK ALHFELPLKI
     ADYLIETFKS NAKALIKGLE ALVLRLHLDA KHSITALSVT ATKALLIDLI EEEQKTAITP
     QKIIQAVAEQ YGIRTEDILG KAQTRECALP RQLAMHLCRE QLKMPFMKIG DLFSRDHSTV
     MSSVKSIQKS LEQDDREISG ICHIILKKLQ G