ID   DNAA2_CHLTR             Reviewed;         455 AA.
AC   O84277;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 2;
GN   Name=dnaA2; OrderedLocusNames=CT_275;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001273; AAC67868.1; -; Genomic_DNA.
DR   PIR; H71534; H71534.
DR   RefSeq; NP_219780.1; NC_000117.1.
DR   RefSeq; WP_009871622.1; NC_000117.1.
DR   AlphaFoldDB; O84277; -.
DR   SMR; O84277; -.
DR   STRING; 813.O172_01485; -.
DR   EnsemblBacteria; AAC67868; AAC67868; CT_275.
DR   GeneID; 884847; -.
DR   KEGG; ctr:CT_275; -.
DR   PATRIC; fig|272561.5.peg.294; -.
DR   HOGENOM; CLU_026910_3_2_0; -.
DR   InParanoid; O84277; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..455
FT                   /note="Chromosomal replication initiator protein DnaA 2"
FT                   /id="PRO_0000114163"
FT   BINDING         154..161
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  51330 MW;  F593F8FBB50A91F1 CRC64;
     MLTCNDCSTW EQFVNYIKTR CSKTAFENWI APIQVLEESS EKIRLEIPNI FVQSYLLDNY
     KKDLCSFVPL DAEGNPALEF VVAEIKRSSP LVTPSIAKPA TEVSEENKDF QLKLNGAYRF
     DNFIEGPSNQ FVKSAALGIA ARPGRSYNPL FIHGGVGLGK THLLHAVGHY VREHHKNLRI
     HCITTEAFIN DLVHHLRVKS IDKMKNFYRS LDLLLVDDIQ FLQNRQNFEE EFCNTFETLI
     HLSKQIVVTS DKPPGQLKLS ERIIARMEWG LVAHVGVPDL ETRVAILQHK AEQKGLNIPN
     EIAFYIADHV YGNVRQLEGA INKLTAYCLL FNKPLTETTV RDTLKELFRA PSKQKVSVES
     ILKSVATVFQ VKIQDLKGSS RAKNVPLARQ VAMYLAKTLI TDSLVAIGAA FGKTHSTVLY
     ACKTIEQKIE KDALLKNQIS LCKNNIAIDS PQHFV