DNAA2_PARUW
ID DNAA2_PARUW Reviewed; 448 AA.
AC Q6MEG8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Chromosomal replication initiator protein DnaA 2 {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA2 {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=pc0307;
OS Protochlamydia amoebophila (strain UWE25).
OC Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC Candidatus Protochlamydia.
OX NCBI_TaxID=264201;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWE25;
RX PubMed=15073324; DOI=10.1126/science.1096330;
RA Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA Mewes H.-W., Wagner M.;
RT "Illuminating the evolutionary history of chlamydiae.";
RL Science 304:728-730(2004).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
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DR EMBL; BX908798; CAF23031.1; -; Genomic_DNA.
DR RefSeq; WP_044044722.1; NC_005861.1.
DR AlphaFoldDB; Q6MEG8; -.
DR SMR; Q6MEG8; -.
DR STRING; 264201.pc0307; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_2_0; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR Proteomes; UP000000529; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..448
FT /note="Chromosomal replication initiator protein DnaA 2"
FT /id="PRO_0000114227"
FT BINDING 153..160
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 448 AA; 50817 MW; E5E32F109C20F6A7 CRC64;
MLTSETQNVW TQFLQFVKTR CSPAAFGNWL APIRVIDCST EEVTLEIPNI FVQEYLLSNY
KKDLCAFLPV DMSGEPAIRF IIAPPQKKII PPNHFSISSS QKEEQSPNSD VKLNNNYRFE
NFIEGPTNQF VKSAAMGVAL RPGQSYNPLF IHGGVGLGKT HILHSIGHYI KENHKKLRVQ
CITTEAFIND LVDSLRNKSV DRMKKFYRSE IDVLLVDDIQ FLQNRLNFEE ELSYTFEALK
NKGAQIVITS DKPPSLLKLS ERTIGKMEGG LVAHMGIPEL ETRVAILQYK AEQKGLHIPH
KVAFFIAEHI HNNVRQLEGA INRLSAHCRL LDLNITEELV SRTLREMLQQ APREKISVEQ
ILKSVAAVFQ VRVSDLRGST RTKDIALPRQ VAMYLAKEMI NESLIMLGAS FGKTHSTILH
ACKNIEKKVA SDETLRRQIG MVRRNIES