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DNAA_ACHLA
ID   DNAA_ACHLA              Reviewed;         445 AA.
AC   Q9KHU8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA;
OS   Acholeplasma laidlawii.
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC   Acholeplasma.
OX   NCBI_TaxID=2148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PG-8B;
RX   PubMed=10779957;
RA   Taganov K.D., Gushchin A.E., Akopian T.A., Oparina N.Y., Abramycheva N.Y.,
RA   Govorun V.M.;
RT   "Analysis of genes, coding for DNA gyrase from the mycoplasma Acholeplasma
RT   laidlawii PG-8B.";
RL   Mol. Biol. (Mosk.) 34:292-299(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AF248639; AAF75986.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9KHU8; -.
DR   SMR; Q9KHU8; -.
DR   PRIDE; Q9KHU8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..445
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114117"
FT   BINDING         144..151
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   445 AA;  51047 MW;  A6045EE53F8C9DB3 CRC64;
     MSPNSTLWQT ILQDLEKLYN EETYNELFLP VTSTFKDQNG LLTMVVANEF LKNRINKLYI
     AKINELATKY SSTPVRLKFV SQEEVIEEPV ADRKLTIDYR QGNLNSTYTF DSFVVGKSNM
     FAFRMAMKVA DHPGAVANPF YIFGDVGLGK THLMQAIGNY ILDNDVEKRI LYVKADNFIE
     DFVSLLSRNK NKTEEFNAKY KDIDVILVDD IQIMANASKT QMEFFKLFDY LYLNNKQIVI
     TSDKPASQLT NIMPRLTTRF EAGLSVDIQI PELEHRISIL KRKTATLDAN LEVSEDILTF
     IASQFAANIR EMEGALIRLI SYAQTFNLEI TMNVVEEALG AVLKTKKKTN DLNENNYDKI
     QSIVADYFQV SLPDLIGKKR HAKFTLPRHI AMYLIKLKYN IPYKTIGSLF NDRDHSTVLS
     ACEKVERDMR MDSNLKFAVD SIVKK
 
 
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