DNAA_BACFR
ID DNAA_BACFR Reviewed; 476 AA.
AC Q64PL4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=BF3825;
OS Bacteroides fragilis (strain YCH46).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=295405;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YCH46;
RX PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT regulating cell surface adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC Rule:MF_00377}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP006841; BAD50567.1; -; Genomic_DNA.
DR RefSeq; WP_005798188.1; NC_006347.1.
DR RefSeq; YP_101101.1; NC_006347.1.
DR AlphaFoldDB; Q64PL4; -.
DR SMR; Q64PL4; -.
DR STRING; 295405.BF3825; -.
DR EnsemblBacteria; BAD50567; BAD50567; BF3825.
DR GeneID; 66331544; -.
DR KEGG; bfr:BF3825; -.
DR PATRIC; fig|295405.11.peg.3673; -.
DR HOGENOM; CLU_026910_3_0_10; -.
DR OMA; FPAFKIV; -.
DR Proteomes; UP000002197; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..476
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114128"
FT BINDING 173..180
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ SEQUENCE 476 AA; 54183 MW; FDE3BB56280B973C CRC64;
MSESSHVGLW NRCLEIIRDN VPESTYKTWF VPIVPLKYED KTLIVQVPSQ FFYEFLEDKF
VDLLRKTLYK VIGDGTKLMY NVLVDKSSGA TVNQESTTRS TAIPQSGLPR VDERKAPGLL
RAPAVQDLDP HLNPNYNFET FIEGYSNKLS RSVAEAVAEN PAKTVFNPLF LHGASGVGKT
HLANAIGTRI KELYPDKRVL YVSAHLFQVQ YTDSVRNNTT NDFINFYQTI DVLIIDDIQE
FAGVTKTQNT FFHIFNHLHQ NGKQLILTSD RAPVLLQGME ERLLTRFKWG MVAELEKPTV
ELRKNILRNK IHRDGLQFPS EVIDYIAENV NESVRDLEGI VISIMAHSTI YNKEIDLDLA
QRIVRKVVRC ETKAVTIDDI INVVCKHFDL ESSAIHTKSR KREVVQARQV AMYLAKTHTD
FSTSKIGKFI GNKDHATVLH ACKTVKGQCE VDKGFRSDLE NIETLLKKRN VSNGER