ID   DNAA_BARHE              Reviewed;         494 AA.
AC   Q6G526;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=BH01180;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF26933.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX897699; CAF26933.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011180075.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G526; -.
DR   SMR; Q6G526; -.
DR   STRING; 283166.BH01180; -.
DR   PaxDb; Q6G526; -.
DR   PRIDE; Q6G526; -.
DR   EnsemblBacteria; CAF26933; CAF26933; BH01180.
DR   GeneID; 64156420; -.
DR   KEGG; bhe:BH01180; -.
DR   eggNOG; COG0593; Bacteria.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..494
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114135"
FT   BINDING         192..199
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   494 AA;  55577 MW;  2E4AC0C0278D7529 CRC64;
     MTDVDSKVVG NASLEHPVIS EEEGAAAFAR VMAQLKAQVG IEAYTSWFGR LKLAEYSRNL
     VKLSVPTAFL RSWINNHYGS LLTNLWKQEN SAILRVEVIV RGMKRVSKAV VCGKNAAPVV
     LEEKTASSFL ENYTEHSVRG VEAGIFGSPL DSRYTFESFV EGSSNRVALA AARSIAEGHK
     SALRFNPLFI HASVGLGKTH LLQAIAAAAL KRLKPARVIY LTAEYFMWRF ATAIRDNDAL
     SFKEQLRDID LLIIDDMQFL QGKSIQNEFC HLLNMLLDSA KQVVVAADRP PSELESLDLR
     VRSRLQGGVA LEIEAPDYEM RLEMLRQRLK VAQQDDNMIV ISDEVLQYIA KTILGSGRDI
     EGAFNQLLFR QSFESDLSLE RIDEFLGHLT RSGESKRIRI EEIQRAVARH YNVSKQDLLS
     NRRTRTVVKP RQVAMYLAKM LTPRSLPEIG RRFGGRDHTT VLHAVRKIED LVCDDQTLAK
     ELELLKRLIG EQAA