ID   DNAA_BIFA0              Reviewed;         583 AA.
AC   B8DV06;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=BLA_0001;
OS   Bifidobacterium animalis subsp. lactis (strain AD011).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=442563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AD011;
RX   PubMed=19011029; DOI=10.1128/jb.01515-08;
RA   Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H.,
RA   Kim D.-W., Ji G.E., Park H.-S., Oh T.K.;
RT   "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp.
RT   lactis AD011.";
RL   J. Bacteriol. 191:678-679(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; CP001213; ACL28307.1; -; Genomic_DNA.
DR   RefSeq; WP_004219016.1; NC_011835.1.
DR   AlphaFoldDB; B8DV06; -.
DR   SMR; B8DV06; -.
DR   STRING; 442563.BLA_0001; -.
DR   EnsemblBacteria; ACL28307; ACL28307; BLA_0001.
DR   GeneID; 66532374; -.
DR   KEGG; bla:BLA_0001; -.
DR   PATRIC; fig|442563.4.peg.1; -.
DR   HOGENOM; CLU_026910_2_2_11; -.
DR   OMA; FPAFKIV; -.
DR   Proteomes; UP000002456; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..583
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000189782"
FT   REGION          86..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         277..284
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   583 AA;  64801 MW;  4EDA0431A1861F57 CRC64;
     MNAENLDPAT QAQTIWSDTL ALIKQNSRLT AREQGWLAGV TAEAVVGTTI ILDVENAQTL
     QVLQTELNEP IIGALEIANG GSPMFPAFKV MPPAQPEPQT TASPEDSGSR AADAQGAAKE
     SVQPDEDSRT PRHSAEQTGD SRPAAAQERE DSAVHMARPD EQTAESHREP EHEPAQQPVT
     SHYDEAIVQT FEDIDPVAGF GPSVAGTTAP QYPPQSEMQG SFTPGVTGNY RDPVTHLNSN
     DTFDTFIQGD SNRFARTVAL AVAEGSGRDY NPLCIYGGSG LGKTHLLHAI GNYAVQNQKP
     RPRVLYVTSE EFTNDFIESI RTSGQDNEDP AMEKFYRKYR EVDVLLIDDI QFLGGKRGIL
     EQFFHTFNSL YQANKRIVIA SDVPPHNLED FEDRLISRFE QGITVDVKPP NLETRIAILR
     MLAEQNHIRV PNDVLNLIAE RFANNVRELE GALKRVIAMA SLNHQPVTRA LTERTLQDFF
     TTDVEVKPTD IIARVAKYFH LTFDDIVGPG RPRSVTLARQ IAMYLTRDMT SMSLMNIGQI
     FGGRDHTTVM HACKHIADKM QEKQEIYNYV NELTVELKQH LND