ID   DNAA_BIFLD              Reviewed;         500 AA.
AC   B3DP22;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=BLD_1436;
OS   Bifidobacterium longum (strain DJO10A).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=205913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DJO10A;
RX   PubMed=18505588; DOI=10.1186/1471-2164-9-247;
RA   Lee J.H., Karamychev V.N., Kozyavkin S.A., Mills D., Pavlov A.R.,
RA   Pavlova N.V., Polouchine N.N., Richardson P.M., Shakhova V.V.,
RA   Slesarev A.I., Weimer B., O'Sullivan D.J.;
RT   "Comparative genomic analysis of the gut bacterium Bifidobacterium longum
RT   reveals loci susceptible to deletion during pure culture growth.";
RL   BMC Genomics 9:247-247(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; CP000605; ACD98881.1; -; Genomic_DNA.
DR   RefSeq; WP_007051767.1; NC_010816.1.
DR   AlphaFoldDB; B3DP22; -.
DR   SMR; B3DP22; -.
DR   EnsemblBacteria; ACD98881; ACD98881; BLD_1436.
DR   GeneID; 66504248; -.
DR   KEGG; blj:BLD_1436; -.
DR   HOGENOM; CLU_026910_2_2_11; -.
DR   OMA; FPAFKIV; -.
DR   Proteomes; UP000002419; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..500
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000121949"
FT   BINDING         197..204
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   500 AA;  55309 MW;  5902D25DEFBF28F5 CRC64;
     MVNASGDPVI EAAHIWSDTL TVLKHSASLS PREKGWLEGV VPEGVFGSTI VLCVDNNDTL
     QAIQGDLNDS LLQALRTVTG ENMFPAFKVV PKTEPEPLSE AKPAQPYPSE ISPTVAEFGK
     ESYGAKPAAA PREPMPATEP QFPVGQQKMN RDPETHLNKN FTFDSFVPGD SNRFARTVAL
     AVAEGSGQDF NPLCIYGGSG LGKTHLLNAI GNYALVKDPG LKVRYVTSEE FTNEFIDALQ
     NPNQSQGQIA EFNRRYRQVD VLLIDDIQFL GGKEATLDQF FHTFNALHQA NKRIVIASDV
     APKNLKGFEA RLISRFESGL TVDVKPPDLE TRIAILRMIA SMNGSKIPSD VLDLIAERFT
     ENIRELEGAL TRVTAVASLS NQPVTRALAE QTLQDFFTTD VEIKPTDIIS QVAKYFHLTF
     EDLVGKSRTK NVAVPRQIAM YLAREMTSMS LMDIGQVFGG RDHTTVMHAC TRISDRMQQK
     QEIYNYVMEL TVRLKQSNTN