ID   DNAA_BIFLO              Reviewed;         500 AA.
AC   Q8G6K0;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=BL0640;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
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DR   EMBL; AE014295; AAN24462.1; -; Genomic_DNA.
DR   RefSeq; NP_695826.1; NC_004307.2.
DR   RefSeq; WP_007051767.1; NC_004307.2.
DR   AlphaFoldDB; Q8G6K0; -.
DR   SMR; Q8G6K0; -.
DR   STRING; 206672.BL0640; -.
DR   EnsemblBacteria; AAN24462; AAN24462; BL0640.
DR   GeneID; 66504248; -.
DR   KEGG; blo:BL0640; -.
DR   PATRIC; fig|206672.9.peg.1371; -.
DR   HOGENOM; CLU_026910_2_2_11; -.
DR   OMA; FPAFKIV; -.
DR   PhylomeDB; Q8G6K0; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..500
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114138"
FT   BINDING         197..204
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   500 AA;  55309 MW;  5902D25DEFBF28F5 CRC64;
     MVNASGDPVI EAAHIWSDTL TVLKHSASLS PREKGWLEGV VPEGVFGSTI VLCVDNNDTL
     QAIQGDLNDS LLQALRTVTG ENMFPAFKVV PKTEPEPLSE AKPAQPYPSE ISPTVAEFGK
     ESYGAKPAAA PREPMPATEP QFPVGQQKMN RDPETHLNKN FTFDSFVPGD SNRFARTVAL
     AVAEGSGQDF NPLCIYGGSG LGKTHLLNAI GNYALVKDPG LKVRYVTSEE FTNEFIDALQ
     NPNQSQGQIA EFNRRYRQVD VLLIDDIQFL GGKEATLDQF FHTFNALHQA NKRIVIASDV
     APKNLKGFEA RLISRFESGL TVDVKPPDLE TRIAILRMIA SMNGSKIPSD VLDLIAERFT
     ENIRELEGAL TRVTAVASLS NQPVTRALAE QTLQDFFTTD VEIKPTDIIS QVAKYFHLTF
     EDLVGKSRTK NVAVPRQIAM YLAREMTSMS LMDIGQVFGG RDHTTVMHAC TRISDRMQQK
     QEIYNYVMEL TVRLKQSNTN