ID   DNAA_BORBU              Reviewed;         486 AA.
AC   P33768;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=BB_0437;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=212;
RX   PubMed=8359672; DOI=10.1111/j.1574-6968.1993.tb06369.x;
RA   Old I.G., Margarita D., Saint-Girons I.;
RT   "Unique genetic arrangement in the dnaA region of the Borrelia burgdorferi
RT   linear chromosome: nucleotide sequence of the dnaA gene.";
RL   FEMS Microbiol. Lett. 111:109-114(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; U04527; AAA58941.1; -; Genomic_DNA.
DR   EMBL; AE000783; AAB91515.1; -; Genomic_DNA.
DR   PIR; D70154; D70154.
DR   RefSeq; NP_212571.1; NC_001318.1.
DR   RefSeq; WP_002656657.1; NC_001318.1.
DR   AlphaFoldDB; P33768; -.
DR   SMR; P33768; -.
DR   STRING; 224326.BB_0437; -.
DR   PRIDE; P33768; -.
DR   EnsemblBacteria; AAB91515; AAB91515; BB_0437.
DR   KEGG; bbu:BB_0437; -.
DR   PATRIC; fig|224326.49.peg.828; -.
DR   HOGENOM; CLU_026910_3_1_12; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000001807; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..486
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114140"
FT   BINDING         183..190
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  56783 MW;  27CA6BE6A9BA39BC CRC64;
     MEKSKNIWSL ILTEIKKELS EEEFYVWFEN LCFLESIGDN IKISTPNLFH KNQIEKRFTK
     KIKEILIKNG YNNIVIVFTN QPPKTHSNKQ ETKNPALNET FSKFDKLKEK TTSKEAIQNI
     QDRIKMYIKK EEEEPTNFKN PFLKKRYTFE NFIIGPNNKL AYNASLSISK NPGKKYNPCL
     IYGGVGLGKT HLLQSIGNKT EELHHNLKIL YVTAENFLNE FVESIKTHET KKFKKKYRYL
     DMLLIDDIHD LQKKEGIQEE LFHTFNALYE DNKQLVFTCD RSPSELTNFT DRLKSRFTRG
     LNVDISKPNF ELRAAIVEKK AEEDGINVPK NILNLVAQKV TTNVRDLEAA VTKLKAYIDL
     DNIEIDIEIV EKIIKEIIIY EKETTNEPNN KINIENIKKI LLRELKITHK DIEGHSKKPE
     ITKARHIYAY LLRNFTELST VEIGKIIGGK THSTVLYSIN KIDRDRNNDK EINNLITELM
     NKIKKN