DNAA_BUCAP
ID DNAA_BUCAP Reviewed; 454 AA.
AC P29434;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Chromosomal replication initiator protein DnaA;
GN Name=dnaA; OrderedLocusNames=BUsg_012;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1572539; DOI=10.1016/0378-1119(92)90393-4;
RA Lai C.-Y., Baumann P.;
RT "Genetic analysis of an aphid endosymbiont DNA fragment homologous to the
RT rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria.";
RL Gene 113:175-181(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9516544; DOI=10.1007/pl00006760;
RA Clark M.A., Baumann L., Baumann P.;
RT "Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera
RT aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon,
RT gidA, and rho.";
RL Curr. Microbiol. 36:158-163(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR EMBL; M80817; AAA73149.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF008210; AAC38106.1; -; Genomic_DNA.
DR EMBL; AE013218; AAM67584.1; -; Genomic_DNA.
DR PIR; JC1158; IQJVBA.
DR RefSeq; WP_011053550.1; NC_004061.1.
DR AlphaFoldDB; P29434; -.
DR SMR; P29434; -.
DR STRING; 198804.BUsg_012; -.
DR PRIDE; P29434; -.
DR EnsemblBacteria; AAM67584; AAM67584; BUsg_012.
DR KEGG; bas:BUsg_012; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_0_1_6; -.
DR OMA; REFNPLF; -.
DR OrthoDB; 219876at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT CHAIN 1..454
FT /note="Chromosomal replication initiator protein DnaA"
FT /id="PRO_0000114149"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 454 AA; 52527 MW; A989508297256C3C CRC64;
MSLCLWKQCL DRLQSELPST EFSMWIRSLK AKLNNNILEI YAPNQFILDW VKDKYLIHFK
KILQDFCGSN SPFIKFKVYQ TSKEKKFKKN ILQKIQNLNA KPIWDKIPIF KKSSHRSNIN
KKHSFENFIE GKSNQLARAA ASQVAKNPGN SYNPLFLYGG TGLGKTHLLH AIGNGILAYK
YNVKIIYMHS ERFVQDMVKA LQNNAIEKFK LYYRSVDALL IDDIQFFAHK ERSQEEFFHT
FNALLEGNQQ IILTSDRYPK EINGVEDRLK SRFGWGLTVA IDPPELETRV AILIKKADEN
NIVLSDEVAF FIAKHLRSNV RELEGALNRV IVNANFTHRS ITVEFVREAL RDILALQEKL
VTIANIQKTV AEYYKIKVAD LLSRRRSRSV ARPRQMAMAM AKELTNHSLP EIGDAFSGRD
HTTVLHACRK IEQLRKENHD IKEDFSNLIR TLSV