ID   DNAA_CAMJE              Reviewed;         440 AA.
AC   Q9PJB0; Q0PCC4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Chromosomal replication initiator protein DnaA;
GN   Name=dnaA; OrderedLocusNames=Cj0001;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
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DR   EMBL; AL111168; CAL34182.1; -; Genomic_DNA.
DR   PIR; D81415; D81415.
DR   RefSeq; WP_002858822.1; NC_002163.1.
DR   RefSeq; YP_002343473.1; NC_002163.1.
DR   AlphaFoldDB; Q9PJB0; -.
DR   SMR; Q9PJB0; -.
DR   IntAct; Q9PJB0; 7.
DR   STRING; 192222.Cj0001; -.
DR   PaxDb; Q9PJB0; -.
DR   PRIDE; Q9PJB0; -.
DR   EnsemblBacteria; CAL34182; CAL34182; Cj0001.
DR   GeneID; 904342; -.
DR   KEGG; cje:Cj0001; -.
DR   PATRIC; fig|192222.6.peg.1; -.
DR   eggNOG; COG0593; Bacteria.
DR   HOGENOM; CLU_026910_3_1_7; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..440
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_0000114152"
FT   BINDING         143..150
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  49686 MW;  A3FAB90CCE0D6BD7 CRC64;
     MNPSQILENL KKELSENEYE NYLSNLKFNE KQSKADLLVF NAPNELMAKF IQTKYGKKIA
     HFYEVQSGNK AIINIQAQSA KQSNKSTKID IAHIKAQSTI LNPSFTFESF VVGDSNKYAY
     GACKAIAHKD KLGKLYNPIF VYGPTGLGKT HLLQAVGNAS LEMGKKVIYA TSENFINDFT
     SNLKNGSLDK FHEKYRNCDV LLIDDVQFLG KTDKIQEEFF FIFNEIKNND GQIIMTSDNP
     PNMLKGITER LKSRFAHGII ADITPPQLDT KIAIIRKKCE FNDINLSNDI INYIATSLGD
     NIREIEGIII SLNAYATILG QEITLELAKS VMKDHIKEKK ENITIDDILS LVCKEFNIKP
     SDVKSNKKTQ NIVTARRIVI YLARALTALT MPQLANYFEM KDHTAISHNV KKITEMIEND
     ASLKAKIEEL KNKILVKSQS